Neonatal exposure to estradiol decreases hypothalamic allopregnanolone concentrations and alters agonistic and sexual but not affective behavior in adult female rats
Neonatal exposure to estradiol decreases hypothalamic allopregnanolone concentrations and alters agonistic and sexual but not affective behavior in adult female rats
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DOI：
10.1016/j.yhbeh.2013.12.009
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发表时间：
2014-02-01
影响因子：
3.5
通讯作者：
Concas, A.
中科院分区：
文献类型：
--
作者：
Berretti, R.;Santoru, F.;Concas, A.
暴露的发展中的雌性大鼠在围产期雌二醇诱导长期的性腺轴失调，并减少皮质和血浆中的allopregnanolone浓度。我们现在已经研究了雌性大鼠新生儿雌二醇给药对下丘脑别孕烯醇酮浓度和探索，情感，激动和性行为以及社会学习的影响。在出生当天单次给予S-雌二醇3-苯甲酸酯（EB，10 μ g）导致阴道开放延迟，无周期性和卵巢衰竭。这些变化与下丘脑中的alopregnanolone的浓度在21和60天，但不是在7天，胎盘的显着下降。新生期给予EB也增加成年大鼠的激动行为，如支配行为和卵巢切除入侵者，而生活攻击不受影响。EB-处理的大鼠也表现出增加肛门生殖器调查，与急剧减少自发和诱导女性性行为（接受性和感知性）。与此相反，新生儿管理EB并没有影响自发活动，焦虑和情绪相关的行为，口味偏好的社会传播，癫痫发作的敏感性。雌二醇的这些作用表明，它在调节别孕烯醇酮的丰度和激动性行为和性行为的表达方面起着重要作用，而不能影响情感行为和社会学习。因此，下丘脑allopregnanolone浓度的显著和持续降低可能与激动和性行为的表现有关。(C)2013 Elsevier Inc. All rights reserved.
Exposure of developing female rats to estradiol during the perinatal period induced long-lasting dysregulation of gonadal axis and decreased cerebrocortical and plasma concentrations of allopregnanolone. We have now examined the effects of neonatal estradiol administration in female rats on hypothalamic allopregnanolone concentrations and on exploratory, affective, agonistic and sexual behaviors as well as social learning. A single administration of S-estradiol 3-benzoate (EB,10 mu g) on the day of birth resulted in a delay of vaginal opening, acyclicity and ovarian failure. These alterations were associated with a significant decrease in the concentrations of allopregnanolone in the hypothalamus at 21 and 60 days, but not at 7 days, afterbirth. Neonatal administration of EB also increased agonistic behaviors in adult rats, such as dominant behaviors and following of an ovariectomized intruder, while living attacks unaffected. EB-treated rats showed also an increase in anogenital investigation, associated with a drastic reduction in spontaneous and induced female sexual behaviors (receptivity and proceptivity). In contrast, neonatal administration of EB did not affect locomotor activity, anxiety- and mood-related behaviors, the social transmission of flavor preferences, and seizures sensitivity. These effects of estradiol suggest that it plays a major role in regulation of both the abundance of allopregnanolone and the expression of agonistic and sexual behaviors, while failing to influence affective behaviors and social learning. Thus, the pronounced and persistent decrease in hypothalamic allopregnanolone concentration may be related to the manifestation of agonistic and sexual behaviors. (C) 2013 Elsevier Inc. All rights reserved.