Resting-state fMRI reveals enhanced functional connectivity in spatial navigation networks after transcranial direct current stimulation
Resting-state fMRI reveals enhanced functional connectivity in spatial navigation networks after transcranial direct current stimulation
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DOI：
10.1016/j.neulet.2015.07.042
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发表时间：
2015-09-14
影响因子：
2.5
通讯作者：
Hampstead, Benjamin M.
中科院分区：
文献类型：
--
作者：
Krishnamurthy, Venkatagiri;Gopinath, Kaundinya;Hampstead, Benjamin M.
A number of studies have established that transcranial direct current stimulation (tDCS) modulates cortical excitability. We previously demonstrated polarity dependent changes in parietal lobe blood oxygen level dependent (BOLD) fMRI in a group of young adults during a spatial navigation task [15]. Here we used resting state functional connectivity (rsFC) to examine whether analogous changes were also evident during the resting state. Participants were randomized to either a parietal-anodal, frontal-cathodal (P+F-) or the opposite montage (P-F+) and received 20 min of tDCS (2 mA) before undergoing restingstate fMRI. rsFC was evaluated between the groups by placing a seed in the medial superior parietal lobule (mSPL), which was under the target electrode. rsFC between the mSPL and a number of other areas involved in spatial navigation, scene processing, and sensorimotor processing was significantly higher in the P+F- than the P-F+ group. Thus, the modulatory effects of tDCS were evident during rest and suggest that stimulation primes not just the underlying neocortex but an extended network that can be recruited as necessary during active task performance. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
