Sarcoidosis: Family Contact Study
Sarcoidosis: Family Contact Study
复制标题
结节病：家庭接触研究
作者：
E. Fité;J. M. Alsina;J. Antó;Josep Morera
目的：评估本地区结节病的家族聚集性。方法：对1986~1988年间西班牙加泰罗尼亚医疗中心确诊为结节病的患者进行回顾性分析。共记录结节病245例(年发病率：1.36/10万居民)。最后，在1990年对188例结节病患者进行了电话问卷调查。结果：这些病例报告了3,757名家庭接触者，其中5人确诊为结节病。家族性结节病的临床表现与非家族性结节病相似，但L综合征较突出。在家庭接触者中结节病的患病率为1.33/1000。结论：家族性关联较低，与本社区年发病率较低相对应。
Aim: To assess the familial aggregation in sarcoidosis in our environment. Methods: The medical centers of Catalonia (Spain) were approached to identify, retrospectively, patients diagnosed as sarcoidosis from 1986 to 1988. 245 sarcoidosis cases were recorded (annual incidence: 1.36/100,000 inhabitants). Finally, in 1990 a telephone questionnaire was administered to 188 sarcoidosis cases. Results: These cases reported 3,757 familial contacts, 5 of whom had confirmed sarcoidosis. The clinical presentation of familial sarcoidosis was similar to nonfamilial sarcoidosis, only Löfgren syndrome stood out. The prevalence of sarcoidosis among familial contacts was 1.33/1,000. Conclusions: The familial association is low and corresponds with the low annual incidence in our community.