Two halosesquiterpenes from Laurencia composita
Two halosesquiterpenes from Laurencia composita
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两种来自 Laurencia composita 的卤代半萜
DOI：
10.1039/c2ra23101h
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发表时间：
2013-01-01
期刊：
影响因子：
3.9
通讯作者：
Ji, Nai-Yun
中科院分区：
文献类型：
--
作者：
Li, Xiao-Dong;Miao, Feng-Ping;Ji, Nai-Yun
从海洋红藻Laurencia composita中分离得到两个新的chamigrane型倍半萜烯化合物：yicterpenes A（1）和B（2），它们的C-9位有一个前所未有的卤代反应，C-10位有一个半缩酮单元。通过核磁共振、电子捕获、质谱和量子化学计算等方法确定了它们的结构和绝对构型。在C-9位氯化的化合物1比在C-9位溴化的化合物2对一些测试的海洋来源的生物更有活性。
Two new chamigrane sesquiterpenes, yicterpenes A (1) and B (2) each with an unprecedented halogenation at C-9 and a hemiketal unit at C-10, were isolated from the marine red alga Laurencia composita. The structures and absolute configurations of them were identified by NMR, ECD, and mass spectrometric methods as well as quantum chemical calculations. Compound 1 with a chlorination at C-9 was more active against some tested marine-derived organisms than 2 with a bromination at C-9.