Functional non-coding RNAs in vascular diseases.

Functional non-coding RNAs in vascular diseases.
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DOI:
10.1111/febs.15678
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发表时间:
2021-11
期刊:
The FEBS journal
影响因子:
--
通讯作者:
--
中科院分区:
其他
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最近,基因组技术的进步,如RNA测序和全基因组图谱,使相当数量的非编码RNA(NcRNAs)的识别成为可能。几十年来,人们一直在研究microRNAs,从而识别出那些在血管疾病中具有致病和/或保护作用的微RNA。虽然其他的ncRNAs,如长的ncRNAs还没有被完全描述,但最近的研究表明它们在血管疾病的发生发展中具有重要的功能。本文综述了目前对ncRNAs机制和功能的认识,重点介绍了小RNA、环状RNA和长ncRNAs在血管疾病中的作用。通过RNA测序和全基因组图谱分析,已经鉴定出相当数量的非编码RNA。这些包括研究了几十年的microRNAs和其他非编码RNAs(NcRNAs),如长的ncRNAs。最近的研究表明,它们在血管疾病的发生发展中具有重要作用。在这里,我们总结了目前对这些ncRNAs的机制和功能的理解。
Recently, advances in genomic technology such as RNA sequencing and genome‐wide profiling have enabled the identification of considerable numbers of non‐coding RNAs (ncRNAs). MicroRNAs have been studied for decades, leading to the identification of those with disease‐causing and/or protective effects in vascular disease. Although other ncRNAs such as long ncRNAs have not been fully described yet, recent studies have indicated their important functions in the development of vascular diseases. Here, we summarize the current understanding of the mechanisms and functions of ncRNAs, focusing on microRNAs, circular RNAs and long ncRNAs in vascular diseases. Considerable numbers of non‐coding RNAs have been identified by RNA sequencing and genome‐wide profiling. These include microRNAs studied for decades and other non‐coding RNAs (ncRNAs) such as long ncRNAs. Recent studies have indicated their important functions in the development of vascular diseases. Here, we summarize the current understanding of the mechanisms and functions of these ncRNAs.
DOI: 10.1038/nature08195
发表时间: 2009-08-06
期刊: Nature
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