Association of Fcγ receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese:: a common susceptibility gene in the Asian populations
Association of Fcγ receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese:: a common susceptibility gene in the Asian populations
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DOI：
10.1111/j.1399-0039.2004.00142.x
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发表时间：
2004-01-01
期刊：
影响因子：
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通讯作者：
Tokunaga, K
中科院分区：
文献类型：
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作者：
Chu, ZT;Tsuchiya, N;Tokunaga, K
Fc γ受体（Fc γ R）多态性与系统性红斑狼疮（SLE）的相关性已在不同人群中得到证实;然而，结果并不一致。我们最近确定了一个单核苷酸多态性编码的非同义取代，Ile 232 Thr（I232 T），FCGR 2B及其与SLE在日本和泰国。多个FcgammaR功能基因（FCGR 2A、FCGR 2B、FCGR 3A和FCGR 3B）在1 q23上具有多态性，并且其中一些处于连锁不平衡（LD）。为了区分来自多连锁基因座的贡献，不同群体的比较可以提供有用的信息。本研究分析了上述4个FCGR基因多态性与SLE的相关性。检测167例SLE患者和129例健康对照者的FCGR 2A-H131 R、FCGR 2B-I232 T、FCGR 3A-F176 V和FCGR 3B基因型。相关性采用病例对照分析。FCGR 2B-232 T和FCGR 3A-176 F等位基因频率在SLE患者中显著增高[比值比（OR）分别为1.67和1.41]。有趣的是，虽然这些等位基因在对照中具有阳性LD的趋势，但在SLE中FCGR 2B-232 T与FCGR 3A-176 V正相关，表明这两个等位基因以独立的方式与SLE相关。FCGR 2B-232 T与SLE肾炎的发生有显著相关性（OR = 2.65）。当目前的结果与我们以前的数据结合起来，日本和泰国使用荟萃分析方法，观察到FCGR 2B和FCGR 3A基因型的高度显着和独立的关联。提示FCGR 2B是亚洲人SLE的一个常见易感因子。
The association of Fcgamma receptor (FcgammaR) polymorphisms with systemic lupus erythematosus (SLE) has been demonstrated in various populations; however, the results have been inconsistent. We recently identified a single-nucleotide polymorphism encoding a non-synonymous substitution, Ile232Thr (I232T), of FCGR2B and its association with SLE in Japanese and in Thais. Multiple functional FcgammaR genes with polymorphisms (FCGR2A, FCGR2B, FCGR3A, and FCGR3B) cluster in 1q23, and some of them are in linkage disequilibrium (LD). To differentiate contributions from multiple-linked loci, comparison of different populations may provide useful information. In this study, we analyzed the above four FCGR polymorphisms of the Chinese patients and controls for the association with SLE. FCGR2A-H131R, FCGR2B-I232T, FCGR3A-F176V, and FCGR3B genotypes were determined in 167 Chinese patients with SLE and 129 healthy controls. Association was examined using case-control analysis. Allele frequencies of FCGR2B-232T and FCGR3A-176F were significantly increased in SLE [odds ratio (OR) = 1.67 and OR = 1.41, respectively]. Interestingly, while these alleles had a tendency of positive LD in the controls, FCGR2B-232T was in positive association with FCGR3A-176V in SLE, suggesting that these two alleles were associated with SLE in an independent manner. Comparison between SLE with and without nephritis indicated significant association of FCGR2B-232T with nephritis (OR = 2.65). When the present results were combined with our previous data on the Japanese and the Thais using meta-analytic methods, highly significant and independent association was observed for FCGR2B and FCGR3A genotypes. These results strongly suggested that FCGR2B is a common susceptibility factor to SLE in the Asians.