Effects of body fatness and physical activity on cardiovascular risk:: Risk prediction using the bioelectrical impedance method
Effects of body fatness and physical activity on cardiovascular risk:: Risk prediction using the bioelectrical impedance method
复制标题
DOI：
10.1080/14034940600595621
复制
发表时间：
2006-12-01
影响因子：
3.4
通讯作者：
Janzon, Lars
中科院分区：
文献类型：
--
作者：
Calling, Susanna;Hedblad, Bo;Janzon, Lars
目的：探讨体脂百分比（BF%）对心血管疾病（CVD）发病率和死亡率的影响，以及与BF%相关的体力活动对心脏的保护作用。研究方法：对26，942名年龄在45-73岁、无CVD病史的男性和女性进行了随访，以了解7年内与BF%的性别特异性四分位数（Q1-Q4）相关的冠状动脉事件（CE）、缺血性卒中和CVD死亡率的发生率。研究了闲暇时间体力活动的心脏保护作用与BF%的关系。结果：在男性中，CE和CVD死亡率的相对危险度（RR）随着BF%的增加而逐渐增加。与Q1相比，Q4中CE的RR为1.37（95%置信区间：1.07-1.74），经年龄、身高、吸烟、高酒精摄入量和体力活动调整。在女性中，BF%与CE和卒中的发生率显著相关。女性BF%与体重指数（BMI）（r=50.83）和腰围（r=0.76）的相关性高于男性（分别为r=0.59和r=50.66）。在女性中，BF%是比BMI更强的危险因素，与腰围同样强。BF%和性别之间存在显著的相互作用（CE发生率p=0.013，缺血性卒中p=0.026）。在BF%高的受试者中，体力活动降低了心血管风险。结论：BF%是CE、缺血性卒中和CVD死亡率的危险因素。BF%和性别之间的相互作用表明BF%是女性中更强的CVD风险因素。与高BF%相关的心血管风险增加可通过体力活动降低。
Aims: To explore the effects of body fat percentage (BF%) on incidence of and mortality from cardiovascular disease (CVD) and to study the cardio-protective effect of physical activity in relation to BF%. Methods: A total of 26,942 men and women, aged 45-73 years, without history of CVD were followed up for incidence of coronary events (CE), ischaemic stroke, and CVD mortality over seven years in relation to sex-specific quartiles (Q1-Q4) of BF%. The cardio-protective effect of leisure-time physical activity was studied in relation to BF%. Results: In men, the relative risk (RR) for CE and CVD mortality increased progressively with BF%. RR for CE in Q4 was 1.37 (95% confidence interval: 1.07-1.74), adjusted for age, height, smoking, high alcohol intake, and physical activity, compared with Q1. In women, BF% was significantly associated with incidence of CE and stroke. BF% was more strongly correlated to body mass index (BMI) (r=50.83) and waist circumference (r=0.76) in women than in men (r=0.59 and r=50.66, respectively). BF% was a stronger risk factor than BMI in women, and equally strong as waist circumference. A significant interaction (p=0.013 for incidence of CE, p=0.026 for ischaemic stroke) was found between BF% and sex. The raised cardiovascular risk was reduced by physical activity in subjects with high BF%. Conclusions: BF% is a risk factor for CE, ischaemic stroke, and CVD mortality. An interaction between BF% and sex suggests that BF% is a stronger CVD risk factor in women. The raised cardiovascular risk associated with high BF% is reduced by physical activity.