Neosappanone A, a xanthine oxidase (XO) inhibitory dimeric methanodibenzoxocinone with a new carbon skeleton from Caesalpinia sappan
Neosappanone A, a xanthine oxidase (XO) inhibitory dimeric methanodibenzoxocinone with a new carbon skeleton from Caesalpinia sappan
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DOI：
10.1016/j.tetlet.2004.09.107
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发表时间：
2004-11-08
影响因子：
1.8
通讯作者：
Kadota, S
中科院分区：
文献类型：
--
作者：
Nguyen, MTT;Awale, S;Kadota, S
从云实（CaesalpiniacetanL.）心材中分离得到一个新的二聚亚甲基二苯并氧杂辛酮（methanodibenzoxocinone），命名为新appanone A（1），具有一个前所未有的新型碳骨架。根据波谱分析鉴定了该化合物的结构。新萨帕酮A（1）以浓度依赖性方式竞争性抑制黄嘌呤氧化酶（IC 50，29.7 μ M; Ki，16.3 μ M）。(C)2004爱思唯尔有限公司保留所有权利。
A novel dimeric methanodibenzoxocinone, named neosappanone A (1), possessing a unique unprecedented novel carbon framework, has been isolated from the heartwood of Caesalpinia sappan L. of Vietnam, and its structure was elucidated on the basis of spectroscopic analysis. Neosappanone A (1) competitively inhibited xanthine oxidase in a concentration-dependent manner (IC50, 29.7 muM; K-i, 16.3 muM). (C) 2004 Elsevier Ltd. All rights reserved.