Two brain cholecystokinin receptors: implications for behavioral actions
Two brain cholecystokinin receptors: implications for behavioral actions
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DOI：
10.1016/0006-8993(86)91413-7
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发表时间：
1986-01
期刊：
影响因子：
2.9
通讯作者：
T. Moran;P. Robinson;M. Goldrich;P. McHugh
中科院分区：
文献类型：
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作者：
T. Moran;P. Robinson;M. Goldrich;P. McHugh
采用[125I]CCK-33体外放射自显影技术测定大鼠脑内CCK受体的分布和相对特异性。我们发现了两种不同的结合模式，表明两种CCK受体类型。第一种是普遍存在的，相对来说没有特异性。第二种，定位于少数皮质下核，具有胰腺CCK受体的特异性。这种受体类型定位于脑后区域，为循环CCK提供了一个可能进入大脑的位置，(1)可以区分CCK和胃泌素，(2)可以介导CCK的一些行为效应。
The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that (1) would distinguish between CCK and gastrin and (2) could mediate some of CCK's behavioral effects.