A polymorphism in human CD1A is associated with susceptibility to tuberculosis.
A polymorphism in human CD1A is associated with susceptibility to tuberculosis.
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CD 1蛋白是抗原呈递分子，其进化为向T细胞呈递脂质而不是肽。然而，与主要组织相容性复合体基因不同，CD 1基因表现出低的多态性，并没有明确与人类疾病。我们报告称，CD 1A（rs 411089）的内含子多态性与两个越南成年人队列的结核病易感性相关（合并队列优势比1.78; 95%CI：1.24-2.57; p=0.001）。这些数据加强了CD 1A介导的脂质抗原呈递对控制人类结核病很重要的假设。
CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease. We report that an intronic polymorphism in CD1A (rs411089) is associated with susceptibility to tuberculosis in two cohorts of Vietnamese adults (combined cohort odds ratio 1.78; 95%CI: 1.24-2.57; p=0.001). These data strengthen the hypothesis that CD1A-mediated lipid antigen presentation is important for controlling tuberculosis in humans.