EFFECTS OF GEOPHAGIA (KAOLIN INGESTION) ON MATERNAL BLOOD AND EMBRYONIC-DEVELOPMENT IN PREGNANT RAT
EFFECTS OF GEOPHAGIA (KAOLIN INGESTION) ON MATERNAL BLOOD AND EMBRYONIC-DEVELOPMENT IN PREGNANT RAT
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DOI：
10.1093/jn/107.11.2020
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发表时间：
1977-01-01
影响因子：
4.2
通讯作者：
STASZAK, DJ
中科院分区：
文献类型：
--
作者：
PATTERSON, EC;STASZAK, DJ
食土癖，以吃粘土的形式，经常在人类怀孕期间被观察到。本研究的目的是确定高岭土（粘土）摄食对孕鼠母体血液和胚胎发育的影响。雌性Sprague-Dawley大鼠36只，分为3组：对照组、20%高岭土饲粮和补铁20%高岭土饲粮。分别在受精前37 ~ 68 d、69 ~ 95 d和96 ~ 117 d饲喂3种饲粮，并在整个妊娠期饲喂相同的饲粮。饲喂高岭土饲料的大鼠Hb、红细胞压积和红细胞水平显著降低，表明母体贫血。高岭土喂养的大鼠的出生体重也显著减少。饲喂高岭土的大鼠接受铁补充后，红细胞压积、血红蛋白、红细胞水平和幼鼠体重均维持在正常范围内。
Geophagia, in the form of clay-eating is often observed during pregnancy in the human population. The intent of this study was to determine the effects of kaoline (clay) ingestion on the maternal blood and embryonic development of the pregnant rat. Sprague-Dawley female rats (36) were divided into 3 groups: control diet, 20% kaolin diet and iron-supplemented 20% kaolin diet. The diets were fed 37-68 days, 69-95 days and 96-117 days prior to fertilization, and the same diets were fed for the duration of the gestation period. The rats fed the kaolin diet exhibited significant reduction in Hb, hematocrit and red blood cell levels, indicating maternal anemia. There was also a significant reduction in the birth weight of the pups born to kaolin fed rats. The kaolin fed rats receiving an iron supplement maintained hematocrit, Hb, red blood cell levels and pup weight within the normal range.