A Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition
A Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition
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DOI：
10.1016/j.cub.2020.11.019
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发表时间：
2021-02-22
期刊：
影响因子：
9.2
通讯作者：
Mallet, Nicolas P.
中科院分区：
文献类型：
--
作者：
Aristieta, Asier;Barresi, Massimo;Mallet, Nicolas P.
基底神经节（BG）通过两个独立的回路抑制运动：纹状体神经元间接和丘脑底核超直接途径。这些途径对外部苍白球（GPe）神经元产生相反的影响，其作为中继的功能重要性随着两种不同细胞类型（即原型和arkypallidal神经元）的发现而发生了巨大变化。然而，鲜为人知的是，不同的GPe神经元对运动抑制通路的突触连接方案，以及如何相反的变化GPe神经元活动与运动抑制。在这里，我们光遗传学解剖原型和arkypallidal神经元的输入组织，并进一步定义与间接或超直接通路激活相关的电路机制和行为结果。这项工作表明，arkypallidal神经元是一种新的双突触反馈回路的一部分，差异招募的间接或hyperdirect途径和广播抑制控制运动只有当arkypallidal神经元增加其活动。
The basal ganglia (BG) inhibit movements through two independent circuits: the striatal neuron-indirect and the subthalamic nucleus-hyperdirect pathways. These pathways exert opposite effects onto external globus pallidus (GPe) neurons, whose functional importance as a relay has changed drastically with the discovery of two distinct cell types, namely the prototypic and the arkypallidal neurons. However, little is known about the synaptic connectivity scheme of different GPe neurons toward both motor-suppressing pathways, as well as how opposite changes in GPe neuronal activity relate to locomotion inhibition. Here, we optogenetically dissect the input organizations of prototypic and arkypallidal neurons and further define the circuit mechanism and behavioral outcome associated with activation of the indirect or hyperdirect pathways. This work reveals that arkypallidal neurons are part of a novel disynaptic feedback loop differentially recruited by the indirect or hyperdirect pathways and that broadcasts inhibitory control onto locomotion only when arkypallidal neurons increase their activity.