Effects of ethanol in an experimental model of combined traumatic brain injury and hemorrhagic shock.
Effects of ethanol in an experimental model of combined traumatic brain injury and hemorrhagic shock.
复制标题
乙醇对创伤性脑损伤和失血性休克联合实验模型的影响。
DOI：
10.1111/j.1553-2712.1998.tb02568.x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Chudnofsky,CC
中科院分区：
文献类型：
--
作者：
Zink,BJ;Stern,SA;Wang,X;Chudnofsky,CC
Objectives:Given that clinical and laboratory studies suggest that ethanol and hemorrhagic shock (HS) potentiate traumatic brain injury (TBI), the authors studied the effects of ethanol in a model of combined TBI and HS.Methods:A controlled porcine model of combined TBI and HS was evaluated for the effect of ethanol on survival time, hemodynamic function, and cerebral tissue perfusion. Anesthetized swine (17–24 kg) were instrumented, splenectomized, and subjected to fluid percussion TBI with concurrent 25‐mL/kg graded hemorrhage over 30 minutes. Two groups were studied: control (n= 11) and ethanol (n= 11). Ethanol, 3.5 g/kg intragastric, was given 100 minutes prior to TBI/HS. Systemic and cerebral physiologic and metabolic parameters were monitored for 2 hours without resuscitation. Regional cerebral blood flow (rCBF) and renal blood flow were measured with dye‐labeled microspheres. Data were analyzed with 2‐sample t‐test and repeated‐measures ANOVA.Results:Ethanol levels at the time of injury were 162 ± 68 mg/dL. Average TBI was 2.65 ± 0.35 atm. Survival time was significantly shorter in the ethanol group (60 ± 27 min vs 94 ± 28 min, p = 0.011). The ethanol group had significantly lower mean arterial pressure, cerebral perfusion pressure, and cerebral venousO2saturation in the postinjury period. Cerebral O2extraction ratios and cerebral venous lactate levels were significantly higher in the ethanol group. A trend toward lower postinjury rCBF in all brain regions was observed in the ethanol group.Conclusion:In this TBI/HS model, ethanol administration decreased survival time, impaired the hemodynamic response, and worsened measures of cerebral tissue perfusion.
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DOI：
--
发表时间：
1989
期刊：
Pharmacology, Biochemistry and Behavior
影响因子：
--
作者：
M. Durcan;R. Lister
通讯作者：
R. Lister
乙醇会损害治疗犬失血性休克的心脏循环功能。
影响因子：
3.8
作者：
J. Horton
通讯作者：
J. Horton
乙醇调节血浆去甲肾上腺素对创伤和出血的反应
影响因子：
1.7
作者：
H. Newsome
通讯作者：
H. Newsome
尽管全身氧输送正常化，脑损伤后的出血性低血压仍会导致脑氧输送早期持续减少。
DOI：
10.1097/00005373-199206000-00007
发表时间：
1992
期刊：
The Journal of trauma
影响因子：
--
作者：
Schmoker,JD;Zhuang,J;Shackford,SR
通讯作者：
Shackford,SR
影响因子：
4.8
作者：
JAGGER, J;FIFE, D;JANE, JA
通讯作者：
JANE, JA