Postpartum dietary intake, depression and the concentration of docosahexaenoic acid in mature breast milk in Wuhan, China
Postpartum dietary intake, depression and the concentration of docosahexaenoic acid in mature breast milk in Wuhan, China
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DOI：
10.1039/d2fo03129a
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发表时间：
2023-02-13
期刊：
影响因子：
6.1
通讯作者：
Yang, Xuefeng
中科院分区：
文献类型：
--
作者：
Cao, Yuan;Wei, Qiaosi;Yang, Xuefeng
背景：二十二碳六烯酸(DHA，C22：6)是母乳中的一种重要脂肪酸，对婴儿生长发育和认知发育具有重要作用。然而，影响母乳中DHA浓度的因素还没有完全弄清楚。目的：本研究旨在了解武汉市中国地区产后妇女母乳中脂肪酸组成的特点，并找出与母乳DHA浓度相关的母体因素。方法：采用气相色谱-质谱法对115例哺乳期妇女产后30-120天的乳汁脂肪酸进行分析。母亲的社会人口、健康和其他信息是通过自我报告的问卷收集的。通过24小时膳食回忆法收集母亲膳食摄入量信息。产后抑郁状态采用爱丁堡产后抑郁量表(EPDS)进行评估。结果：母乳中DHA的平均含量为0.49%。多因素回归分析显示，乳汁中DHA比例与母亲食用水产品(β=0.183，95%CI：0.052，0.314)和补充DHA(β=0.146，95%CI：0.108，0.185)呈正相关，与产后抑郁状态(β=-0.122，95%CI：-0.243，-0.002)呈负相关。结论：增加产妇水产品摄入量和DHA补充量，改善产后抑郁状态，可提高哺乳期妇女母乳中DHA浓度。
Background: Docosahexaenoic acid (DHA, C22:6) is an important fatty acid in breast milk and is essential for infantile growth and cognitive development. However, the factors that affect the DHA concentration in breast milk have not been completely clarified. Objective: This study aimed to characterize the composition of breast milk fatty acids and to identify maternal factors associated with breast milk DHA concentration in postpartum women in Wuhan, China. Methods: In this cross-sectional study, we analyzed milk fatty acids in 115 lactating women at 30-120 days postpartum using GC-MS. Maternal sociodemographic, health and other information were collected using a self-reported questionnaire. Maternal dietary intake information was collected through a 24-hour dietary recall method. Postpartum depression status was identified using the Edinburgh Postnatal Depression Scale (EPDS). Results: The mean DHA proportion in breast milk was 0.49%. The multivariate regression model showed that the milk DHA proportion was positively associated with maternal aquatic product intake (beta = 0.183, 95%CI: 0.052, 0.314) and DHA supplement use (beta = 0.146, 95%CI: 0.108, 0.185), and negatively associated with postpartum depression status (beta = -0.122, 95%CI: -0.243, -0.002) after adjustment for several maternal and infant factors. Conclusion: Increasing maternal aquatic product intake and DHA supplement use and improving postpartum depression status may increase DHA concentration in breast milk in lactating women.