Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study.
Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study.
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运转良好的老年人的步行速度缓慢和心血管死亡：前瞻性队列研究。
DOI：
10.1136/bmj.b4460
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发表时间：
2009-11-10
期刊：
影响因子：
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通讯作者：
Tzourio C
中科院分区：
文献类型：
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作者：
Dumurgier J;Elbaz A;Ducimetière P;Tavernier B;Alpérovitch A;Tzourio C
目的研究老年人步行速度慢与死亡风险的关系，包括总体和主要死因。设计前瞻性队列研究。设置第戎戎中心（法国）的三个城市的研究。研究对象为1999 - 2001年在社区招募的3208名年龄≥65岁的男性和女性，平均随访5.1年。主要结果测量死亡率，总体和根据主要死亡原因，按基线步行速度的三分之一（以超过6米的最大速度测量），校正几个潜在的混杂因素;按基线步行速度的三分之一绘制Kaplan-Meier生存曲线。随访期间的生命状态。死因。结果在16414人年的随访中，209名参与者死亡（99人死于癌症，59人死于心血管疾病，51人死于其他原因）。基线步行速度最低三分之一的参与者与基线步行速度最高三分之一的参与者相比，死亡风险增加（风险比1.44，95%置信区间1.03至1.99）。对具体死亡原因的分析表明，与步行速度较快的参与者相比，步行速度较慢的参与者心血管死亡风险增加了约三倍（2.92，1.46至5.84）。与癌症死亡率无相关性（1.03，0.65 ~ 1.70）。在分层分析中，心血管死亡率在按性别、中位年龄、中位体重指数（BMI）和体力活动水平定义的各个分层中增加。结论老年人步行速度慢与心血管死亡风险增加密切相关。
Objective To study the relation between low walking speed and the risk of death in older people, both overall and with regard to the main causes of death. Design Prospective cohort study. Setting Dijon centre (France) of the Three-City study. Participants 3208 men and women aged ≥65 living in the community, recruited from 1999 to 2001, and followed for an average of 5.1 years. Main outcome measures Mortality, overall and according to the main causes of death, by thirds of baseline walking speed (measured at maximum speed over six metres), adjusted for several potential confounders; Kaplan-Meier survival curves by thirds of baseline walking speed. Vital status during follow-up. Causes of death. Results During 16 414 person years of follow-up, 209 participants died (99 from cancer, 59 from cardiovascular disease, 51 from other causes). Participants in the lowest third of baseline walking speed had an increased risk of death (hazard ratio 1.44, 95% confidence interval 1.03 to 1.99) compared with the upper thirds. Analyses for specific causes of death showed that participants with low walking speed had about a threefold increased risk of cardiovascular death (2.92, 1.46 to 5.84) compared with participants who walked faster. There was no relation with cancer mortality (1.03, 0.65 to 1.70). In stratified analyses, cardiovascular mortality was increased across various strata defined by sex, median age, median body mass index (BMI), and level of physical activity. Conclusion Slow walking speed in older people is strongly associated with an increased risk of cardiovascular mortality.