Lorazepam and diazepam impair true, but not false, recognition in healthy volunteers
Lorazepam and diazepam impair true, but not false, recognition in healthy volunteers
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DOI：
10.1007/s002130100683
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发表时间：
2001-05-01
影响因子：
3.4
通讯作者：
Danion, JM
中科院分区：
文献类型：
--
作者：
Huron, C;Servais, C;Danion, JM
理由：苯二氮卓类药物对记忆的有害影响已有充分记录。然而，它们对错误记忆的影响是未知的。目的：本研究旨在探讨劳拉西泮和地西泮对健康志愿者错误记忆和相关意识状态的影响。研究方法：在36名健康志愿者中使用Deese/Roediger-McDermott程序，这些志愿者被随机分配到三个平行组之一（安慰剂、地西泮0.3 mg/kg、劳拉西泮0.038 mg/kg）。受试者研究了与非呈现主题词（关键诱惑）语义相关的单词列表。在一个识别记忆任务与先前提出的话和非提出的关键诱惑，他们被要求记住，知道或猜测的项目，有意识的回忆，熟悉，或猜测的基础上认识的反应，分别。结果如下：苯二氮卓类药物组正确识别的单词比例和与真正识别相关的记住反应比例低于安慰剂组。相比之下，苯二氮卓类药物并没有显著影响错误识别的关键诱饵的比例或与错误识别相关的记住反应的比例。结论：这些结果表明，地西泮和劳拉西泮损害与真实记忆有关的意识回忆，但不损害虚假记忆。
Rationale: The deleterious effects of benzodiazepine on memory are well documented. However, their effects on false memories are unknown. Objective: The aim of this study was to investigate the effects of lorazepam and diazepam on false memories and related states of awareness in healthy volunteers. Methods: The Deese/Roediger-McDermott procedure was used in 36 healthy volunteers randomly assigned to one of three parallel groups (placebo, diazepam 0.3 mg/kg, lorazepam 0.038 mg/kg). Subjects studied lists of words semantically related to a non-presented theme word (critical lure). On a recognition memory task with both previously presented words and non presented critical lures, they were asked to give Remember, Know or Guess responses to items that were recognized on the basis of conscious recollection, familiarity, or guessing, respectively. Results: The proportions of studied words correctly recognized and the proportions of Remember responses associated with true recognition were lower in the benzodiazepine groups than in the placebo group. In contrast, benzodiazepines did not significantly influence the proportions of critical lures falsely recognized or the proportions of Remember responses associated with false recognition. Conclusion: These results indicate that diazepam and lorazepam impair conscious recollection associated with true, but not false, memories.