Volumetric and shape analysis of thalamus in idiopathic generalized epilepsy
Volumetric and shape analysis of thalamus in idiopathic generalized epilepsy
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DOI：
10.1007/s00415-013-6891-5
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发表时间：
2013-07-01
影响因子：
6
通讯作者：
Koh, Seong-Beom
中科院分区：
文献类型：
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作者：
Kim, Ji Hyun;Kim, Jung Bin;Koh, Seong-Beom
先前使用基于体素的形态测量（VBM）的研究提供了特发性全身性癫痫（IGE）丘脑结构变化的新证据。然而，在整个研究中，IGE在丘脑内萎缩的位置有些不一致。因此，我们使用多种分析方法检查了丘脑萎缩的位置及其与IGE临床因素的关系。50例IGE患者和50例对照者进行3T MRI扫描。结构评估包括自动丘脑容积法、VBM和丘脑形状分析。对患者和对照组进行分组比较，以评估丘脑萎缩。在患者中进一步研究丘脑萎缩与临床变量之间的组内相关性。IGE患者两种丘脑体积均减少，且与病程负相关。VBM显示，与对照组相比，患者的双侧前内侧丘脑区域灰质体积显著减少。从丘脑前内侧簇提取的体素值与疾病持续时间呈负相关。基于顶点的形状分析显示，与对照组相比，患者双侧丘脑前内侧和后背侧的区域萎缩。相关分析显示，双侧丘脑前内侧和后背侧与病程呈负相关。结合多项分析，我们证实了IGE患者的丘脑前内侧和后背侧区域萎缩。鉴于这些丘脑区域与额叶的解剖联系，我们的发现与疾病持续时间增加有关的更大的丘脑萎缩进一步支持了IGE下丘脑-额叶网络异常的病理生理学概念，并可能涉及额叶认知功能障碍和疾病进展。
Previous studies using voxel-based morphometry (VBM) provided emerging evidence of structural changes of the thalamus in idiopathic generalized epilepsy (IGE). However, the location of atrophy within the thalamus in IGE has been somewhat inconsistent across the studies. We, therefore, examined the location of thalamic atrophy and its relationship with clinical factors in IGE, using multiple analytic methods. Fifty IGE patients and 50 controls were scanned on a 3T MRI. Structural evaluation consisted of automated thalamic volumetry, VBM, and thalamic shape analysis. Group comparison between patients and controls was made to assess thalamic atrophy. Within-group correlations between thalamic atrophy and clinical variables were further performed in patients. Both thalamic volumes were reduced in IGE patients, and were negatively correlated with disease duration. The VBM showed a significant regional grey matter volume reduction in bilateral anterior-medial thalami in patients compared to controls. Voxel values extracted from the anterior-medial thalamic cluster were negatively correlated with disease duration. Vertex-based shape analysis revealed regional atrophy on the anterior-medial and posterior-dorsal aspects of thalamus bilaterally in patients compared to controls. Correlation analysis showed that anterior-medial and posterior-dorsal aspects of bilateral thalami were negatively correlated with disease duration. Combining multiple analyses, we demonstrated regional atrophy of anterior-medial and posterior-dorsal thalamus in patients with IGE. Given the anatomical connection of these thalamic regions with the frontal lobe, our finding of greater thalamic atrophy in relation to increasing disease duration further supports the pathophysiological concept of thalamo-frontal network abnormality underlying IGE, and may implicate frontal cognitive dysfunctions and disease progression.