Antifungal Polyketides and Other Compounds from Amazonian Endophytic Talaromyces Fungi
Antifungal Polyketides and Other Compounds from Amazonian Endophytic Talaromyces Fungi
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DOI：
10.21577/0103-5053.20170176
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发表时间：
2018-03-01
影响因子：
1.4
通讯作者：
Souza, Antonia Q. L. de
中科院分区：
文献类型：
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作者：
Silva, Paulo H. F. da;Souza, Mayane P. de;Souza, Antonia Q. L. de
对生物活性化合物候选物的持续寻找推动了对由不同生物体产生的新物质的追求。植物内生真菌是一类具有多种生物活性的代谢产物的来源。基于丰富的亚马逊生物多样性和微生物来源的化学潜力，3 Talaromyces菌株，所有主要的内生菌从各自的宿主植物，旨在分离生物活性的次生代谢产物进行了研究。通过经典的色谱方法，从所研究的菌株的抗菌提取物中分离得到13个化合物。从这些，聚酮化合物，类固醇，酸酐和酚类化合物被确定。其中，两个以前未描述的化合物被阐明的基础上，光谱和光谱方法，同源二聚体色满酮和马来酸酐甲酯。评价了提取物、馏分和分离化合物对一组病原微生物的抗微生物活性。
The continuous search for biologically active compound candidates pushes the pursuit of new substances produced by diverse organisms. Endophytic fungi are known as a promising source of metabolites with several biological activities. Based on the rich Amazonian biodiversity and the chemical potential of microbial sources, three Talaromyces strains, all major endophytes from their respective host plants, were studied aiming at the isolation of biologically active secondary metabolites. Through classical chromatographic approaches, 13 compounds were isolated from the antimicrobial extracts of the studied strains. From these, polyketides, steroids, anhydrides, and phenolic compounds were identified. Among them, two previously undescribed compounds were elucidated based on spectroscopic and spectrometric methods, a homodimer chromanone and a maleic anhydride methyl ester. The antimicrobial activity against a panel of pathogenic microorganisms from extracts, fractions, and isolated compounds was evaluated.