Blood pressure, vessel caliber, and retinal thickness in diabetes.
Blood pressure, vessel caliber, and retinal thickness in diabetes.
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DOI：
10.1097/opx.0b013e3182775c62
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Adams AJ
中科院分区：
文献类型：
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作者：
Harrison WW;Chang A;Cardenas MG;Bearse MA Jr;Schneck ME;Barez S;Adams AJ
在这项研究中，我们研究了2型糖尿病和高HbA1c（长期血糖升高）患者的血压（BP），视网膜厚度（RT）和血管口径的相关性，无论是否伴有轻度或中度非增殖性糖尿病视网膜病变（NPDR）。43例HbA1c测量值较高的2型糖尿病患者（23例无NPDR，20例轻度至中度NPDR）和22例年龄匹配的非糖尿病对照组参加了研究。测量BP、RT（Stratus OCT 3）、眼底照相和HbA1c。评估BP、HbA1c、血管口径和RT之间的相关性。1)在NPDR患者中，舒张压与RT显著正相关（p <0.02）。在无NPDR的患者中，BP与视网膜厚度无关（p = 0.83）。2)在NPDR组中，HbA1c升高与舒张压升高之间存在相关性（p<0.02）。此外，HbA1c改变了NPDR患者舒张压和RT之间关系的斜率。3)在对照组中，在有和无NPDR的患者中观察到小静脉直径增大，小动脉直径减小和收缩压升高之间的相关性丧失。这项研究的结果表明，HbA1c和BP一起对糖尿病视网膜病变患者的视网膜厚度测量产生影响。在临床上和将来对该人群进行OCT研究时，在评估糖尿病视网膜病变患者的视网膜厚度时应考虑这些措施。
In this study we examine the association of blood pressure (BP), retinal thickness (RT), and vessel caliber in patients with type 2 diabetes and high HbA1c (elevated long-term blood glucose), either with or without mild or moderate non-proliferative diabetic retinopathy (NPDR). Forty-three type 2 diabetes patients with high HbA1c measures (23 without NPDR and 20 with mild to moderate NPDR) and 22 age-matched, non-diabetic controls participated. BP, RT (Stratus OCT3), fundus photography, and HbA1c were measured. Correlations between BP, HbA1c, vessel caliber, and RT were evaluated. 1) Diastolic BP is positively and significantly associated with RT in patients with NPDR (p <0.02). BP was not associated with retinal thickness in patients without NPDR (p = 0.83). 2) There is an association between higher HbA1c and higher diastolic BP within the NPDR group (p<0.02). Furthermore, HbA1c modifies the slope of the relationship between diastolic BP and RT in NPDR patients. 3) Greater venule diameters and a loss of the correlation between decreased arteriole size and increased systolic blood pressure, seen in controls, were observed in patients with and without NPDR. The results of this study show that HbA1c and BP together have an impact on the retinal thickness measures of patients with diabetic retinopathy. These measures should be considered when evaluating retinal thickness in patients with diabetic retinopathy, both clinically and in future OCT studies on this population.