New A-nor steroids and their antifouling activity from the Chinese marine sponge Acanthella cavernosa
New A-nor steroids and their antifouling activity from the Chinese marine sponge Acanthella cavernosa
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中国海绵 Acanthella Cavernosa 的新 A-nor 类固醇及其防污活性
DOI：
10.1016/j.steroids.2008.08.006
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发表时间：
2008-12-22
期刊：
影响因子：
2.7
通讯作者：
Lin, Wen Han
中科院分区：
文献类型：
--
作者：
Qiu, Yan;Deng, Zhi Wei;Lin, Wen Han
对海绵体棘海绵体进行化学检查，分离出3种新的A环收缩类固醇，即2-羟基-4,7-二酮A-去胆碱-5-烯-2-oic酸乙酯(1)、24s -乙基-2-羟基-4,7-二酮A-去胆碱-5-烯-2-oic酸乙酯(2)、2-羟基-4,7-二酮A- 24r -甲基-去胆碱-5,22(E)-二烯-2-oic酸乙酯(3)，以及其他4种已知类固醇（4-7）。结构是在广泛的光谱分析的基础上确定的。化合物1 ~ 3对白颡鱼的沉降抑制效果较好，EC50值分别为8.2、215、31.6 μ g/mL。(C) 2008爱思唯尔公司版权所有。
A chemical examination of the Chinese sponge Acanthella cavernosa resulted in the isolation of three new A-ring contracted steroids, the ethyl esters of 2 beta-hydroxy-4,7-diketoA-norcholest-5-en-2-oic acid (1), 24S-ethyl-2 beta-hydroxy- 4,7-diketo-A-norcholest-5-en-2-oic acid (2), and 2 beta-hydroxy-4,7-diketo-24R-methyl-A-norcholest-5,22(E)-dien-2-oic acid (3), along with four other known steroids (4-7). The structures were determined on the basis of extensive spectroscopic analysis. Compounds 1-3 showed antifouling activity toward the settlement inhibition of Balanus albicostatus with the EC50 values of 8.2, 215, 31.6 mu g/mL, respectively. (C) 2008 Elsevier Inc. All rights reserved.