NLRP3 inflammasome activation in liver cirrhotic patients
NLRP3 inflammasome activation in liver cirrhotic patients
复制标题
肝硬化患者NLRP3炎症小体激活
DOI：
10.1016/j.bbrc.2018.09.055
复制
发表时间：
2018-10-20
影响因子：
3.1
通讯作者：
Zhang, Xiaohui
中科院分区：
文献类型：
--
作者：
Ma, Xiao;Zheng, Xudong;Zhang, Xiaohui
Aims: NLRP3 inflammasome activation is involved in the mechanism of liver cirrhosis. In this study, we investigated the levels of plasma IL-1 beta and IL-18 and their relationship to component traits in patients with liver cirrhosis, and NLRP3 inflammasome expression in liver of patients with liver cirrhosis.Methods: A total of 75 patients with liver cirrhosis and 41 age-matched healthy control subjects were enrolled in this study. NLRP3 inflammasome expression and activation were measured in liver of patients with liver cirrhosis. Plasma IL-1 beta and IL-18 levels were examined by ELISA in patients with liver cirrhosis.Results: Plasma IL-1 beta and IL-18 levels were also significantly higher in patients with liver cirrhosis than in control subjects. Plasma IL-18 levels were significantly positively associated with Child-Pugh classification, IL-1 beta levels, diastolic blood pressure, aspartate aminotransferase, total bilirubin, direct bilirubin, activated partial thromboplastin timealk and aline phosphatase. Plasma IL-18 levels were significantly negatively associated with albumin. NLRP3 and cleaved caspase-1 expression were increased in the livers of patients with cirrhosis compared with the livers of control subjects.Conclusions: Plasma IL-1 beta and IL-18 levels were higher in plasma in patients with liver cirrhosis than in control subjects, and plasma 1L-18 levels were significantly positively associated with Child-Pugh classification and IL-1 beta levels. In addition, NLRP3 and cleaved caspase-1 expression were increased in the livers of patients with cirrhosis. (C) 2018 Elsevier Inc. All rights reserved.
