Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.
Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.
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DOI：
10.3389/fnint.2011.00068
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发表时间：
2011
影响因子：
3.5
通讯作者：
Keller A
中科院分区：
文献类型：
--
作者：
Dendrinos G;Hemelt M;Keller A
涉及感觉处理障碍的障碍的特征是无法过滤感觉信息，特别是同时到达的多模式输入。我们研究了产前接触丙戊酸(VPA)对幼年和成年大鼠行为的影响，以及对大脑中关键的多感觉整合中心上丘的解剖的影响。丙戊酸是一种与感觉功能障碍有关的致畸物质。暴露于VPA的大鼠表现出丘脑依赖行为的缺陷，包括惊厥反应、脉冲前抑制和伤害性反应。一些赤字随着年龄的增长而逆转。体视学分析显示，VPA处理的大鼠丘脑小白蛋白阳性神经元明显减少，这是GABA能细胞的一个亚群。这些结果表明，产前VPA治疗影响上丘的发育，并导致持续的解剖学变化，在需要感觉处理的任务中表现为异常行为。
Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.