Serum carotenoid concentrations are inversely associated with serum aminotransferases in hyperglycemic subjects
Serum carotenoid concentrations are inversely associated with serum aminotransferases in hyperglycemic subjects
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DOI：
10.1016/j.diabres.2005.05.004
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发表时间：
2006-01-01
影响因子：
5.1
通讯作者：
Nagao, A
中科院分区：
文献类型：
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作者：
Sugiura, M;Nakamura, M;Nagao, A
高血糖会通过葡萄糖自氧化增加自由基的产生，而自由基的增加可能导致肝细胞的损伤。在这项研究中，我们验证了一种假设，即高血糖引起的血清肝酶在其生理浓度范围内的增加与血清抗氧化剂类胡萝卜素水平成反比。研究对象是2003年接受健康检查的857名男性和女性日本人。那些有肝病病史和酗酒者被排除在外。对血清六类胡萝卜素浓度与血清天冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)的相关性进行横断面评估。空腹血糖受损(IFG)组和糖尿病组血清AST、ALT水平明显高于正常组。IFG组和糖尿病组血清AST和ALT的多变量调整平均值与血清β-隐黄素和β-胡萝卜素浓度的三分位数一致，显著低于对照组。血清肝酶和类胡萝卜素浓度在β-隐黄素中的相关性最大。抗氧化剂类胡萝卜素，尤其是β-隐黄素，在高血糖受试者肝功能障碍的早期发病机制中，可能起到阻止血清转氨酶升高的作用。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Hyperglycemia increases the generation of free radicals by glucose auto-oxidation, and the increment of free radicals may lead to liver cell damage. In this study, we tested the hypothesis that hyperglycemia-induced increases of serum liver enzymes among its physiological concentration would be inversely associated with serum antioxidant carotenoid level. Study subjects were 857 male and female Japanese who had received health examinations in 2003. Those with a history of liver disease and excessive alcohol drinkers were excluded. The associations of serum six-carotenoid concentrations with serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) stratified by glucose tolerance status were evaluated cross-sectionally. Serum AST and ALT concentrations in the groups of impaired fasting glucose (IFG) and diabetes were significantly higher than those in the normal group. The multivariate-adjusted means of the serum AST and ALT concentrations in IFG and diabetes group were significantly low in accordance with the tertiles of the serum beta-cryptoxanthin and beta-carotene concentrations. The most inverse association of serum liver enzyme and carotenoid concentration was observed in beta-cryptoxanthin. Antioxidant carotenoid, especially beta-cryptoxanthin, may act a deterrent substance against increasing the serum aminotransferase in the earlier pathogenesis of liver dysfunction among hyperglycemic subjects. (c) 2005 Elsevier Ireland Ltd. All rights reserved.