Mucoid strains of Pseudomonas aeruginosa: the influence of culture medium on the stability of mucus production.
Mucoid strains of Pseudomonas aeruginosa: the influence of culture medium on the stability of mucus production.
复制标题
铜绿假单胞菌的粘液菌株：培养基对粘液产生稳定性的影响。
DOI：
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发表时间：
1975
影响因子：
3
通讯作者：
J. Govan
中科院分区：
文献类型：
--
作者：
J. Govan
从囊性纤维化（CF）患者呼吸道分离的铜绿假单胞菌粘液样菌株，从非CF患者获得的粘液样菌株，以及通过噬菌体作用在体外获得的粘液样菌株，在脱氧胆酸-柠檬酸琼脂上连续传代培养后，发现其粘液样菌落形态稳定。描述了阴离子、阳离子和中性表面活性剂稳定粘液生成的能力。考虑到双棕榈酰卵磷脂作为体内粘液生成的稳定剂的可能重要性，特别是粘液样铜绿假单胞菌在CF疾病中的作用。
Mucoid strains of Pseudomonas aeruginosa isolated from the respiratory tract of patients with cystic fibrosis (CF), those obtained from non-CF patients, and those obtained in vitro by the action of phage, were found to be stable in their mucoid colonial form when serially subcultured on deoxycholate-citrate agar. The ability of anionic, cationic and neutral surfactants to stabilise mucus production is described. The possible importance of dipalmitoyl lecithin as a stabilising agent for mucus production in vivo is considered, with particular reference to the role of mucoid P. aeruginosa in CF disease.