Discrete subregions of the rat midbrain periaqueductal gray project to nucleus ambiguus and the periambigual region
Discrete subregions of the rat midbrain periaqueductal gray project to nucleus ambiguus and the periambigual region
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DOI：
10.1016/s0306-4522(97)00051-1
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发表时间：
1997-10-01
期刊：
影响因子：
3.3
通讯作者：
Rizvi, TA
中科院分区：
文献类型：
--
作者：
Ennis, M;Xu, SJ;Rizvi, TA
我们用逆行和顺行追踪技术研究了大鼠中脑导水管周围灰质到疑核和疑核周围区域的投射组织。逆行追踪结果显示，投射到疑核的神经元来自位于动眼上中央灰质、外侧和腹外侧导水管周围灰质的三个独立的、纵向排列的神经元柱。顺行追踪研究表明，这三个中脑导水管周围灰质神经元的投射终止于疑核和疑核周围区域。双标记研究表明，中脑导水管周围灰质神经元与胆碱能神经元紧密相连，位于疑核的致密、半致密、疏松和外部结构中。目前的结果表明，中脑导水管周围灰质向疑核的投射可能部分地介导了刺激中脑导水管周围灰质产生的某些心血管调节和发声。(C)1997年IBRO。爱思唯尔科学有限公司出版。
We investigated the organization of projections from the rat midbrain periaqueductal gray to nucleus ambiguus and the periambigual region using retrograde and anterograde tract tracing techniques. Retrograde tracing results revealed that neurons that project to nucleus ambiguus arise from three discrete, longitudinally organized columns of neurons located in the supraoculomotor central gray, lateral and ventrolateral periaqueductal gray. Anterograde tracing studies demonstrated that projections from these three columns of periaqueductal gray neurons terminate with topographic specificity in nucleus ambiguus and the periambigual region. Double-labelling studies demonstrated that periaqueductal gray neurons terminate in close contiguity to cholinergic neurons in the compact, semicompact, loose and external formations of nucleus ambiguus.The present results suggest that projections from periaqueductal gray to nucleus ambiguus may mediate, in part, certain cardiovascular adjustments and vocalizations produced by stimulation of periaqueductal gray. (C) 1997 IBRO. Published by Elsevier Science Ltd.