Secretion of alpha subunit of glycoprotein hormones by pituitary adenomas.
Secretion of alpha subunit of glycoprotein hormones by pituitary adenomas.
复制标题
垂体腺瘤分泌糖蛋白激素的α亚基。
DOI：
10.1210/jcem-43-1-97
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
F. Maloof
中科院分区：
文献类型：
--
作者：
I. Kourides;B. Weintraub;S. Rosen;E. Ridgway;B. Kliman;F. Maloof
在60例垂体腺瘤患者中，用灵敏和特异的放射免疫法测定了糖蛋白激素α亚单位（血清α）的血清浓度。5例患者在治疗前血清α显著升高（范围14.5-23.0 ng/ml）。这5例患者包括2例甲状腺功能亢进男性伴血清促甲状腺激素不适当升高，其中1例还患有肢端肥大症，1例男性伴高泌乳素血症和脑脊液α升高，1例绝经后女性伴低血清促性腺激素和高泌乳素血症，1例男性伴中枢性甲状腺功能减退和性腺功能减退。5例患者中有3例在治疗后进行了再研究;这3例患者的血清α从19.5 ng/ml降至10.6 ng/ml，从23.0 ng/ml降至2.0 ng/ml，从17.0 ng/ml降至12.0 ng/ml。3例患者血清中α的洗脱与正常垂体α相似。另55例患者，包括20例肢端肥大症、15例乳管肥大症和2例纳尔逊综合征，血清α <0.5-5.0 ng/ml。此外，22例“空蝶鞍”综合征（无垂体瘤）患者的α小于0.5-5.0 ng/ml。正常男性和绝经前女性的血清α浓度低于0.5-2.5 ng/ml;正常绝经后女性为1.0-7.0 ng/ml;原发性甲状腺功能减退症患者为0.7-9.0 ng/ml。对促甲状腺激素和促黄体生成素释放激素（TRH和LHRH）的α反应降低意味着垂体瘤α分泌的相对自主性; 5例血清α升高的患者的平均α增量在TRH给药后为15%，在LHRH给药后为10%。正常人和原发性甲状腺功能减退症患者在TRH或LHRH后表现出更大的平均α增量百分比。在某些蝶鞍扩大的患者中，TRH和LHRH后血清α升高而分泌很少或没有增加可能提示垂体瘤的存在。
In 60 patients with pituitary adenomas, the serum concentration of the alpha subunit of the glycoprotein hormones (serum alpha) was measured by a sensitive and specific radioimmunoassay. Five patients had markedly elevated serum alpha prior to therapy (range 14.5-23.0 ng/ml). These 5 patients included 2 hyperthyroid men with inappropriately high serum thyrotropin, one of whom also had acromegaly, a man with hyperprolactinemia and elevated cerebrospinal fluid alpha, a postmenopausal woman with low serum gonadotropins and hyperprolactinemia, and a man with central hypothyroidism and hypogonadism. Three of the 5 were restudied after therapy; serum alpha in these three decreased from19.5 to 10.6, 23.0 to 2.0, and 17.0 to 12.0 ng/ml. Alpha in these 3 patinets' serum eluted similarly to normal pituitary alpha by gel chromatography. The other 55 patinets, including twenty with acromegaly, fifteen with galactorrhea, and two with Nelson's syndrome, had serum alpha.less than 0.5-5.0 ng/ml. In addition, 22 patients with "empty sella" syndrome (no pituitary tumor) had alpha less than 0.5-5.0 ng/ml. Normal men and premenopausal women had serum alpha concentrations of less than 0.5-2.5 ng/ml; normal postmenopausal women, 1.0-7.0 ng/ml; and patients with primary hypothyroidism, 0.7-9.0 ng/ml. The decreased alpha response to thyrotropin and luteinizing hormone-releasing hormones (TRH and LHRH) implied a relative autonomy of pituitary tumor alpha secretion; the mean alpha increment in the 5 patients with elevated serum alpha was 15% after TRH administration and 10% after LHRH. Normal individuals and patients with primary hypothyroidism demonstrated greater mean per cent alpha increments after TRH or LHRH. In certain patients with an enlarged sella turcica, an elevated serum alpha with little or no increase in secretion after TRH and LHRH may suggest the presence of pituitary tumor.