Subjective feeling of psychological fatigue is related to decreased reactivity in ventrolateral prefrontal cortex
Subjective feeling of psychological fatigue is related to decreased reactivity in ventrolateral prefrontal cortex
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DOI：
10.1016/j.brainres.2008.11.077
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发表时间：
2009-02-03
期刊：
影响因子：
2.9
通讯作者：
Mikuni, Masahiko
中科院分区：
文献类型：
--
作者：
Suda, Masashi;Fukuda, Masato;Mikuni, Masahiko
本研究旨在探讨主观疲劳与脑功能的关系。23名健康的年轻志愿者参加了这项研究。通过52通道近红外光谱（NIRS）研究了用视觉模拟量表（VAS）评分和睡眠时间评估主观疲劳与语言流畅性任务时大脑皮层反应性之间的关系。在言语流畅性任务中，VAS评分与额叶腹外侧至颞叶上部区域双侧通道氧合血红蛋白浓度（[oxy-Hb]）升高呈负相关。前一晚的睡眠时间与前额叶背外侧双侧通道的增加正相关，在言语流畅性任务中也是如此。在对照任务（左手手指敲击任务）中，VAS评分和前一晚睡眠时间与[oxy-Hb]升高之间没有显著相关性。主观的心理疲劳感觉与前一晚额外侧皮层和颞上皮层反应性降低有关，与睡眠时间无关，反映在前额叶背外侧皮层的反应性。这些结果表明，短暂性功能减退和持续功能障碍的外侧前额叶和颞叶是疲劳的脑底物之一。这也证明了近红外光谱在研究疲劳等主观现象时的大脑功能方面的优势，因为它可以在自然环境中进行检查。(C) 2008 Elsevier B.V.版权所有
The purpose of this study is to examine the relationship between subjective fatigue and brain function. Twenty-three healthy young volunteers participated in this study. Relationships were investigated between subjective fatigue assessed using visual-analogue scale (VAS) score and sleep duration, and cerebral cortex reactivity during a verbal fluency task by 52-channel near-infrared spectroscopy (NIRS). The VAS score negatively correlated with oxygenated hemoglobin concentration ([oxy-Hb]) increases in the bilateral channels over the regions from the ventrolateral part of the frontal lobe to the upper part of the temporal lobe during the verbal fluency task. Sleep duration in the previous night positively correlated with [oxy-Hb] increases in the bilateral channels over the dorsolateral prefrontal lobe also during the verbal fluency task. No significant correlations between the VAS score and sleep duration in the previous night with [oxy-Hb] increases were found during a control task, the left-finger-tapping task. The subjective feeling of psychological fatigue is related to decreased reactivities in the lateral frontal and superior temporal cortices and is unrelated to sleep duration in the previous night, which is reflected in the reactivity in the dorsolateral prefrontal cortices. These results suggest that transient hypofunction and persistent dysfunction in the lateral prefrontal and temporal lobes are among the brain substrates of fatigue. These also demonstrate the advantage of NIRS for investigating brain function during subjective phenomena such as fatigue because it enables examination in a natural setting. (C) 2008 Elsevier B.V. All rights reserved.