Rapid whole-brain quantitative magnetization transfer imaging using 3D selective inversion recovery sequences.
Rapid whole-brain quantitative magnetization transfer imaging using 3D selective inversion recovery sequences.
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DOI：
10.1016/j.mri.2020.01.014
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发表时间：
2020-05
影响因子：
2.5
通讯作者：
Dortch RD
中科院分区：
文献类型：
--
作者：
Cronin MJ;Xu J;Bagnato F;Gochberg DF;Gore JC;Dortch RD
选择性反转恢复（SIR）是一种定量磁化转移（qMT）方法，它提供了白质中髓磷脂含量相关参数的估计，即大分子池大小比（PSR）和自由池的自旋-晶格弛豫率（R1f），而不需要独立估计∆B0， B1+和T1。尽管在人脑中进行SIR的可行性已经得到证实，但之前报道的扫描时间对于全脑应用来说太长了。在这项工作中，我们将优化的短tr采集、SENSE/部分傅里叶加速和高效的3D读数（涡轮自旋回波，SIR-TSE、回波平面成像，SIR-EPI和涡轮场回波，SIR-TFE）结合起来，分别在7分钟、10分钟和18分钟内获得了SIR-TFE、SIR-EPI和SIR-TSE的全脑数据。在数值模拟的基础上，所有方案都能在大的均匀区域提供准确的参数估计；然而，较短的SIR-TFE扫描由于模糊而低估了较小病变的局灶变化。在健康受试者（n=8）中进行的实验研究得出的参数与文献值一致，并且在扫描期间可重复（变异系数：PSR= 2.2-6.4%, R1f= 0.6-1.4%）。总体而言，SIR-TFE参数表现出最低的变异性，而SIR-EPI参数受到与敏感性相关的图像畸变的不利影响。在复发缓解型多发性硬化症患者（n=2）中，使用所有三种读数观察病灶SIR参数的局灶性变化；然而，在较小的SIR-TFE病变中，对比度降低，这与数值模拟一致。总之，这些发现表明，使用3D TFE、EPI或TSE读数可以进行高效、准确和可重复的全脑SIR；但是，应该根据应用程序定制适当的读数。
Selective inversion recovery (SIR) is a quantitative magnetization transfer (qMT) method that provides estimates of parameters related to myelin content in white matter, namely the macromolecular pool-size-ratio (PSR) and the spin-lattice relaxation rate of the free pool (R1f), without the need for independent estimates of ∆B0, B1+, and T1. Although the feasibility of performing SIR in the human brain has been demonstrated, the scan times reported previously were too long for whole-brain applications. In this work, we combined optimized, short-TR acquisitions, SENSE/partial-Fourier accelerations, and efficient 3D readouts (turbo spin-echo, SIR-TSE; echo-planar imaging, SIR-EPI; and turbo field echo, SIR-TFE) to obtain whole-brain data in 7, 10, and 18 minutes for SIR-TFE, SIR-EPI, SIR-TSE, respectively. Based on numerical simulations, all schemes provided accurate parameter estimates in large, homogenous regions; however, the shorter SIR-TFE scans underestimated focal changes in smaller lesions due to blurring. Experimental studies in healthy subjects (n=8) yielded parameters that were consistent with literature values and repeatable across scans (coefficient of variation: PSR=2.2–6.4%, R1f=0.6–1.4%) for all readouts. Overall, SIR-TFE parameters exhibited the lowest variability, while SIR-EPI parameters were adversely affected by susceptibility-related image distortions. In patients with relapsing remitting multiple sclerosis (n=2), focal changes in SIR parameters were observed in lesions using all three readouts; however, contrast was reduced in smaller lesions for SIR-TFE, which was consistent with the numerical simulations. Together, these findings demonstrate that efficient, accurate, and repeatable whole-brain SIR can be performed using 3D TFE, EPI, or TSE readouts; however, the appropriate readout should be tailored to the application.
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影响因子：
5.7
作者：
Dortch, Richard D.;Moore, Jay;Li, Ke;Jankiewicz, Marcin;Gochberg, Daniel F.;Hirtle, Jane A.;Gore, John C.;Smith, Seth A.
通讯作者：
Smith, Seth A.
影响因子：
64.8
作者：
EDZES, HT;SAMULSKI, ET
通讯作者：
SAMULSKI, ET
影响因子：
3.3
作者：
Jenkinson, M;Wilson, JL;Jezzard, P
通讯作者：
Jezzard, P
影响因子：
4.8
作者：
Smith, SM
通讯作者：
Smith, SM
影响因子：
3.3
作者：
CONSTABLE, RT;GORE, JC
通讯作者：
GORE, JC