Silk properties determined by gland-specific expression of a spider fibroin gene family
Silk properties determined by gland-specific expression of a spider fibroin gene family
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DOI：
10.1126/science.272.5258.112
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发表时间：
1996-04-05
期刊：
影响因子：
56.9
通讯作者：
Gosline, JM
中科院分区：
文献类型：
--
作者：
Guerette, PA;Ginzinger, DG;Gosline, JM
蜘蛛产生各种各样的丝，从莱卡样的弹性纤维到凯夫拉样的超级纤维。发现来自蜘蛛园蛛的基因家族编码具有不同比例的无定形富含甘氨酸结构域和由聚（丙氨酸）和聚（甘氨酸-丙氨酸）重复基序构建的晶体结构域的丝形成蛋白（丝素）。蜘蛛通过该基因家族的腺体特异性表达产生不同组成的丝，这允许根据组成丝素蛋白的晶体形成潜力的一系列机械特性。这些纤维性质控制的原则可能是重要的基因工程结构蛋白的发展。
Spiders produce a variety of silks that range from Lycra-like elastic fibers to Kevlar-like superfibers. A gene family from the spider Araneus diadematus was found to encode silk-forming proteins (fibroins) with different proportions of amorphous glycine-rich domains and crystal domains built from poly(alanine) and poly(glycine-alanine) repeat motifs. Spiders produce silks of different composition by gland-specific expression of this gene family, which allows for a range of mechanical properties according to the crystal-forming potential of the constituent fibroins. These principles of fiber property control may be important in the development of genetically engineered structural proteins.