Two faces of BRD4 Mitotic bookmark and transcriptional lynchpin
Two faces of BRD4 Mitotic bookmark and transcriptional lynchpin
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DOI：
10.4161/trns.22542
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发表时间：
2013-01-01
影响因子：
3.6
通讯作者：
Singer, Dinah S.
中科院分区：
文献类型：
--
作者：
Devaiah, Ballachanda N.;Singer, Dinah S.
溴结构域蛋白BRD4连接细胞周期和转录，标记有丝分裂期间的活性基因，并作为转录因子的支架。我们最近发现BRD4是一种RNA聚合酶II CTD激酶，证实了一种新的转录功能。在这里，我们在现有知识的背景下讨论我们的模型。
The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA Polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.