Immunity to Trichuris muris in the laboratory mouse
Immunity to Trichuris muris in the laboratory mouse
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DOI：
10.1079/joh2002162
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发表时间：
2003-06-01
影响因子：
1.6
通讯作者：
deSchoolmeester, ML
中科院分区：
文献类型：
--
作者：
Else, KJ;deSchoolmeester, ML
在所有肠道线虫感染的实验室模型中，小鼠鞭虫可以说是最强大的。这在很大程度上是由于驱逐这种寄生虫的能力是依赖于菌株的。因此，大多数小鼠品系容易驱逐T。穆里斯。然而，某些小鼠品系，以及实际上特定小鼠品系中的一些个体，不能产生保护性免疫应答，并具有长期慢性感染。因此，这种独特的模型提供了一个机会，以检查免疫事件的基础上抵抗感染和持续感染的同一宿主物种，在某些情况下，同一宿主菌株。
Of all the laboratory models of intestinal nematode infection, Trichuris muris in the mouse is arguably the most powerful. This is largely due to the fact that the ability to expel this parasite is strain dependent. Thus, most mouse strains readily expel T. muris. However certain mouse strains, and indeed some individuals within particular mouse strains, are unable to mount a protective immune response and harbour long term chronic infections. This unique model thus presents an opportunity to examine the immune events underlying both resistance to infection and persistent infection within the same host species, and in some cases, the same host strain.