Monocytic TNF alpha secretion patterns in IDDM patients with periodontal diseases
Monocytic TNF alpha secretion patterns in IDDM patients with periodontal diseases
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DOI：
10.1111/j.1600-051x.1997.tb01178.x
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发表时间：
1997-01-01
影响因子：
6.7
通讯作者：
Offenbacher, S
中科院分区：
文献类型：
--
作者：
Salvi, GE;Collins, JG;Offenbacher, S
本研究的目的是确定单核细胞TNF α分泌模式是否可以作为胰岛素依赖型糖尿病（IDDM）患者牙周病易感性的潜在表型标志。在32例胰岛素依赖型糖尿病患者中，分析了脂多糖（LPS）刺激单核细胞TNF α分泌的剂量-反应特征，并与两种不同的牙周状况类别相关。糖尿病患者分为A组（牙龈炎或轻度牙周病）和B组（中重度牙周病）。另外，17名患有不同程度牙周病的非糖尿病患者作为对照组。糖尿病患者作为一个群体，与牙龈炎或成人牙周炎的非糖尿病患者相比，单核细胞对牙龈卟啉单胞菌A 7436脂多糖浓度增加（0、0.003、0.03、0.3和3.0 μ g/ml）的反应显著更高（p
The aim of the present study was to identify whether monocytic TNF alpha secretion patterns could serve as a potential phenotypic discriminator for periodontal disease susceptibility within insulin-dependent diabetes mellitus (IDDM) patients. In 32 IDDM individuals the lipopolysaccharide (LPS) stimulated monocytic TNF alpha secretion dose-response characteristics were analyzed and related to two different periodontal status categories. Diabetics were divided into group A (gingivitis or mild periodontal disease) and group B (moderate to severe periodontal disease). In addition, 17 non-diabetic individuals with various degrees of periodontal disease served as control patients. Diabetics as a group had a significantly higher monocytic TNF alpha production in response to increasing Porphyromonas gingivalis A 7436 lipopolysaccharide concentrations (0, 0.003, 0.03, 0.3 and 3.0 mu g/ml) as compared to non-diabetic patients with gingivitis or adult periodontitis (p