Intravenous immunoglobulin:: An update on the clinical use and mechanisms of action
Intravenous immunoglobulin:: An update on the clinical use and mechanisms of action
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DOI：
10.1007/s10875-007-9088-9
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发表时间：
2007-05-01
影响因子：
9.1
通讯作者：
Kaveri, Srini V.
中科院分区：
文献类型：
--
作者：
Negi, Vir-Singh;Elluru, Sriramulu;Kaveri, Srini V.
静脉注射免疫球蛋白（IVIg）最初用作免疫缺陷疾病的替代疗法，现在广泛用于许多自身免疫性疾病和炎症性疾病。在理解 IVIg 在自身免疫和炎症性疾病中发挥免疫调节作用的机制方面已经取得了相当大的进展。 IVIg的作用机制很复杂，涉及调节Fc受体的表达和功能，干扰补体和细胞因子网络以及独特型网络的激活，调节细胞生长，以及影响树突状细胞、T细胞和B细胞的激活、分化和效应功能。
Initially used as a replacement therapy for immunodeficiency diseases, intravenous immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory diseases. Considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory effects in autoimmune and inflammatory disorders. The mechanisms of action of IVIg are complex, involving modulation of expression and function of Fc receptors, interference with activation of complement and the cytokine network and of idiotype network, regulation of cell growth, and effects on the activation, differentiation, and effector functions of dendritic cells, and T and B cells.