Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging
Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging
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DOI：
10.3174/ajnr.a4722
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发表时间：
2016-07-01
影响因子：
3.5
通讯作者：
Tominaga, T.
中科院分区：
文献类型：
--
作者：
Omodaka, S.;Endo, H.;Tominaga, T.
背景和目的：血管壁 MR 成像中脑动脉瘤壁强化的发生率在破裂的颅内动脉瘤中高于在未破裂的颅内动脉瘤中，但破裂和未破裂的动脉瘤之间强化程度的差异尚不清楚。我们使用定量 MR 成像测量比较了破裂和未破裂颅内动脉瘤之间的增强程度。 材料和方法：我们使用血管壁 MR 成像对 28 个破裂和 76 个连续病例的脑动脉瘤壁周向增强进行了定量分析。注射造影剂前后获得3D-T1加权快速自旋回波序列，并计算壁增强指数。然后我们比较了破裂和未破裂动脉瘤的特征。结果：破裂动脉瘤的壁增强指数显着高于未破裂动脉瘤（分别为 1.70 ± 1.06 与 0.89 +/- 0.88；P = .0001）。受试者工作特征曲线分析发现，区分破裂动脉瘤和未破裂动脉瘤的壁增强指数最可靠的截止值为 0.53（敏感性，0.96；特异性，0.47）。在多变量逻辑回归分析中，壁增强指数仍然显着（P < .0001）。结论：沿脑动脉瘤壁的更大的圆周增强与破裂状态相关。使用血管壁磁共振成像对圆周增强进行定量评估可能有助于区分破裂与未破裂的颅内动脉瘤。
BACKGROUND AND PURPOSE: The incidence of wall enhancement of cerebral aneurysms on vessel wall MR imaging has been described as higher in ruptured intracranial aneurysms than in unruptured intracranial aneurysms, but the difference in the degree of enhancement between ruptured and unruptured aneurysms is unknown. We compared the degree of enhancement between ruptured and unruptured intracranial aneurysms by using quantitative MR imaging measures.MATERIALS AND METHODS: We performed quantitative analyses of circumferential enhancement along the wall of cerebral aneurysms in 28 ruptured and 76 unruptured consecutive cases by using vessel wall MR imaging. A 3D-T1-weighted fast spin-echo sequence was obtained before and after contrast media injection, and the wall enhancement index was calculated. We then compared characteristics between ruptured and unruptured aneurysms.RESULTS: The wall enhancement index was significantly higher in ruptured than in unruptured aneurysms (1.70 1.06 versus 0.89 +/- 0.88, respectively; P = .0001). The receiver operating characteristic curve analysis found that the most reliable cutoff value of the wall enhancement index to differentiate ruptured from unruptured aneurysms was 0.53 (sensitivity, 0.96; specificity, 0.47). The wall enhancement index remained significant in the multivariate logistic regression analysis (P < .0001).CONCLUSIONS: Greater circumferential enhancement along the wall of cerebral aneurysms correlates with the ruptured state. A quantitative evaluation of circumferential enhancement by using vessel wall MR imaging could be useful in differentiating ruptured from unruptured intracranial aneurysms.