Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil.
Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil.
复制标题
青光眼滤过手术术后5-氟尿嘧啶的严重角膜并发症。
DOI：
10.1016/s0002-9394(14)74224-2
复制
发表时间：
1987
影响因子：
4.2
通讯作者：
DriebeJr,WT
中科院分区：
文献类型：
--
作者：
Knapp,A;Heuer,DK;Stern,GA;DriebeJr,WT
我们研究了4名青光眼滤过术后接受5-氟尿嘧啶治疗的患者，他们发生了严重的角膜并发症。所有四名患者都有原有的角膜异常，包括干燥性角膜结膜炎、外露角膜病变和大泡性角膜病变。所有患者在术后期间都出现了上皮缺陷。并发症包括细菌性角膜溃疡(2例)，无菌角膜溃疡和角膜穿孔(1例)，角化性角膜斑块伴无菌基质渗出(1例)。青光眼滤过术后应用5-氟尿嘧啶(一种具有较大角膜上皮毒性的抗代谢药物)经常导致角膜上皮缺损，可能导致继发并发症。接受这种药物的患者应该密切监测他们的角膜状况。对于患有角膜上皮病的患者，应谨慎使用5-氟尿嘧啶。
We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications. All four patients had preexisting corneal abnormalities including keratoconjunctivitis sicca, exposure keratopathy, and bullous keratopathy. All of the patients developed epithelial defects in the postoperative period. The complications included bacterial corneal ulceration (two patients), sterile corneal ulceration and corneal perforation (one patient), and a keratinized corneal plaque with underlying sterile stromal infiltrate (one patient).The use of 5-fluorouracil, which is an antimetabolite with considerable corneal epithelial toxicity, after glaucoma filtering surgery frequently causes corneal epithelial defects that may lead to secondary complications. Patients receiving this drug should have their corneal status closely monitored. In patients with corneal epithelial disease, 5-fluorouracil should be used with caution.