TPC: the NAADP discovery channel?
TPC: the NAADP discovery channel?
复制标题
DOI：
10.1042/bst20140300
复制
发表时间：
2015-06-01
影响因子：
3.9
通讯作者：
Galione, Antony
中科院分区：
文献类型：
--
作者：
Morgan, Anthony J.;Davis, Lianne C.;Galione, Antony
动员钙离子的第二信使--烟酸腺嘌呤二核苷酸磷酸(NAADP)已经存在近20年了，但对于其靶向钙释放通道的定位，我们仍不能完全达成一致。尽管最近对两孔通道(TPC)代表难以捉摸的“NAADP受体”的观点提出了一些强有力的挑战，但仍有越来越多的证据表明TPC对于NAADP介导的反应是重要的。这篇文章将简要概述背景，并回顾与TPC故事有关的更多最近的工作。
The Ca2+ -mobilizing second messenger, NAADP (nicotinic acid adenine dinucleotide phosphate), has been with us for nearly 20 years and yet we still cannot fully agree on the identity of its target Ca2+ -release channel. In spite of some recent robust challenges to the idea that two-pore channels (TPCs) represent the elusive "NAADP receptor", evidence continues to accumulate that TPCs are important for NAADP-mediated responses. This article will briefly outline the background and review more recent work pertaining to the TPC story.