Similarities and interplay between senescent cells and macrophages.
Similarities and interplay between senescent cells and macrophages.
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DOI：
10.1083/jcb.202010162
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Gil J
中科院分区：
文献类型：
--
作者：
Behmoaras J;Gil J
Behmoaras和Gil描述了衰老细胞和巨噬细胞之间的共同细胞特征，并概述了两种细胞类型在动态平衡和疾病期间的相互作用。衰老是一种细胞程序，可以防止衰老、受损或癌细胞的复制。衰老的细胞生长受阻，其形态、染色质组织和代谢发生变化，并产生具有生物活性的分泌体。这种分泌体，衰老相关的分泌表型(SASP)，介导了许多与衰老细胞相关的病理生理效应，例如，招募和激活免疫细胞，如巨噬细胞。衰老细胞和巨噬细胞之间的关系很耐人寻味：衰老细胞招募巨噬细胞，可以诱导它们衰老，或者可以影响它们的极化。衰老细胞和巨噬细胞具有多种表型特征；两者都具有高分泌状态、溶酶体数量增加或激活炎症体的能力。衰老的细胞在衰老和疾病过程中积累，杀死它们会带来广泛的好处。在这里，我们讨论衰老细胞和巨噬细胞之间的相似性，并解释巨噬细胞生物学的最新发展，以了解细胞衰老的分子机制。我们描述了巨噬细胞衰老的证据和影响，并推测了巨噬细胞衰老状态的个体发育。最后，我们研究了炎症条件下和肿瘤微环境中巨噬细胞-衰老细胞的相互作用及其对巨噬细胞效应器功能的影响。
Behmoaras and Gil describe shared cellular features between senescent cells and macrophages and outline the interaction between the two cell types during homeostasis and disease. Senescence is a cellular program that prevents the replication of old, damaged, or cancerous cells. Senescent cells become growth arrested and undergo changes in their morphology, chromatin organization, and metabolism, and produce a bioactive secretome. This secretome, the senescence-associated secretory phenotype (SASP), mediates many of the pathophysiological effects associated with senescent cells, for example, recruiting and activating immune cells such as macrophages. The relation between senescent cells and macrophages is intriguing: senescent cells recruit macrophages, can induce them to undergo senescence, or can influence their polarization. Senescent cells and macrophages share multiple phenotypic characteristics; both have a high secretory status, increased lysosome numbers, or the ability to activate the inflammasome. Senescent cells accumulate during aging and disease, and killing them results in widespread benefits. Here we discuss similarities between senescent cells and macrophages and interpret the latest developments in macrophage biology to understand the molecular mechanisms of cellular senescence. We describe evidence and effects of senescence in macrophages and speculate on the ontogeny of the senescent-like state in macrophages. Finally, we examine the macrophage–senescent cell interplay and its impact on macrophage effector functions during inflammatory conditions and in the tumor microenvironment.
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影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
4.5
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Baillie JK;Arner E;Daub C;De Hoon M;Itoh M;Kawaji H;Lassmann T;Carninci P;Forrest AR;Hayashizaki Y;FANTOM Consortium;Faulkner GJ;Wells CA;Rehli M;Pavli P;Summers KM;Hume DA
通讯作者：
Hume DA
影响因子：
7.8
作者：
Gonzalez-Gualda, Estela;Paez-Ribes, Marta;Munoz-Espin, Daniel
通讯作者：
Munoz-Espin, Daniel
影响因子：
32.4
作者：
Burzynski, Laura C.;Humphry, Melanie;Clarke, Murray C. H.
通讯作者：
Clarke, Murray C. H.
影响因子：
5.5
作者：
Gazova, Iveta;Lefevre, Lucas;Summers, Kim M.
通讯作者：
Summers, Kim M.