Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects.
Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects.
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DOI：
10.1177/1559325817690638
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Tsukimoto M
中科院分区：
文献类型：
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作者：
Kojima S;Ohshima Y;Nakatsukasa H;Tsukimoto M
三磷酸腺苷 (ATP) 作为对多种细胞毒性药物产生适应性反应的信号分子，在介导辐射应激诱导的反应中发挥着重要作用，从而减轻或修复 γ 辐射对身体的有害影响。事实上，低剂量的辐射可能通过激活多种保护机制（包括抗肿瘤免疫反应）而产生净有益效果。另一方面，ATP信号传导可能参与癌细胞的辐射抵抗。在这里，我们重点回顾了我们之前的工作，回顾了低剂量 γ 辐射（0.25-0.5 Gy）诱导细胞外 ATP 释放的证据，并且释放的 ATP 介导多种辐射诱导的反应，包括增加细胞内抗氧化剂合成、细胞介导的免疫反应、诱导 DNA 损伤修复系统和调节性 T 细胞的分化。
Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injurious effects of γ radiation on the body. Indeed, low doses of radiation may have a net beneficial effect by activating a variety of protective mechanisms, including antitumor immune responses. On the other hand, ATP signaling may be involved in the radiation resistance of cancer cells. Here, focusing on our previous work, we review the evidence that low-dose γ irradiation (0.25-0.5 Gy) induces release of extracellular ATP, and that the released ATP mediates multiple radiation-induced responses, including increased intracellular antioxidant synthesis, cell-mediated immune responses, induction of DNA damage repair systems, and differentiation of regulatory T cells.