Structural characterization of a sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice
Structural characterization of a sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice
复制标题
DOI：
10.1007/s00343-021-1307-3
复制
发表时间：
2022
影响因子：
1.6
通讯作者：
Hong Wang
中科院分区：
文献类型：
--
作者：
Songze Ke;Bo Zhang;Yanlei Yu;Sijia Wang;Weihua Jin;Jian Wu;Jianwei Chen;Huawei Zhang;Bin Wei;Hong Wang
A sulfated galactofucan designated as UpG was obtained from the brown algae Undaria pinnatifida by calcium chloride extraction. Chemical analyses showed that UpG is composed of galactose and fucose at a high sulfation level. Low-molecular weight UpGP-0.5 was prepared from UpG through acid hydrolysis for structure characterization. The backbones of UpG are determined to be α-(1,3)-Fuc, α-(1,4)-Gal, α-(1,3)-Gal, and α-(1,6)-Gal by GC-MS, FT-IR, NMR, and LC-MS analyses. Sulfate groups are modified at C2 and/or C4 of fucose and C3 and/or C4 of galactose. UpG could partially lower blood sugar and serum lipid levels in type 2 diabetic mice. Moreover, UpG treatment regulates the abundance of some specific gut microbiota, such as enriching the abundance of Muribaculum and Christensenellaceae, and reducing that of Bilophila, Tannerellaceae, Candidatus Saccharimonas and Anaerotruncus. The findings characterized the detailed structure of a sulfated galactofucan and investigated its potential for the treatment of type 2 diabetes mellitus.
