Taste representations in the Drosophila brain
Taste representations in the Drosophila brain
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DOI：
10.1016/j.cell.2004.06.011
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发表时间：
2004-06-25
期刊：
影响因子：
64.5
通讯作者：
Scott, K
中科院分区：
文献类型：
--
作者：
Wang, ZR;Singhvi, A;Scott, K
果蝇的味觉与身体许多部位的味觉神经元复合，这表明苍蝇可以检测食物来源的位置和质量。例如，腿上味觉神经元的激活导致长鼻的延伸或缩回，而长鼻味觉神经元的激活导致食物摄取或排斥。我们研究了是否味觉的位置和味觉质量的功能映射在苍蝇的大脑中使用分子，遗传和行为的方法。我们发现，这些投射是根据它们所识别的味道类别来区分的：识别糖的神经元投射到一个不同于识别有害物质的区域。转基因轴突标记实验也表明，味觉投射是分离的基础上，他们在周边的位置。这些研究揭示了果蝇大脑第一中继的味觉图，并证明了味觉质量和位置在解剖投影模式中的代表性。
Drosophila taste compounds with gustatory neurons on many parts of the body, suggesting that a fly detects both the location and quality of a food source. For example, activation of taste neurons on the legs causes proboscis extension or retraction, whereas activation of proboscis taste neurons causes food ingestion or rejection. We examined whether the features of taste location and taste quality are mapped in the fly brain using molecular, genetic, and behavioral approaches. We find that projections are segregated by the category of tastes that they recognize: neurons that recognize sugars project to a region different from those recognizing noxious substances. Transgenic axon labeling experiments also demonstrate that gustatory projections are segregated based on their location in the periphery. These studies reveal the gustatory map in the first relay of the fly brain and demonstrate that taste quality and position are represented in anatomical projection patterns.