Usefulness of the BTA stat Test for the diagnosis of bladder cancer
Usefulness of the BTA stat Test for the diagnosis of bladder cancer
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DOI：
10.1016/s0090-4295(00)01090-6
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发表时间：
2001-04-01
期刊：
影响因子：
2.1
通讯作者：
García, BM
中科院分区：
文献类型：
--
作者：
Baños, JLG;Rodrigo, MDR;García, BM
目标.评估Bard BTA stat检测在膀胱癌诊断和随访中的作用，并将其与常规诊断方法细胞学分析和膀胱镜检查进行比较。379例因膀胱癌或有膀胱癌症状的患者接受了膀胱镜检查、细胞学分析和使用最近排泄的尿液样本进行的BTA stat测试。对可疑病例行经尿道电切术和组织病理学检查。在379名患者中，235名被证实患有膀胱癌，144名没有。BTA法、细胞学检查和膀胱镜检查的敏感性分别为73.62%、61.70%和99.57%;特异性分别为83.33%、92.36%和85.42%。BTA stat Test对1级、2级和3级肿瘤的敏感性分别为47.27%、69.15%和95.35%。细胞学检查的敏感性分别为30.91%、55.32%和88.37%。BTA stat检测对Ta期、T1期和T2-4期的敏感性分别为45.65%、75.52%和95.56%，细胞学结果分别为28.26%、65.03%和84.44%。两项联合检测可提高敏感性，但特异性略有下降。BTA stat检测的高灵敏度，以及从用于评价检测的参数中获得的数据，证明了BTA stat检测与细胞学分析相比具有更好的结果，使其成为诊断膀胱癌的彻底有效的诊断工具。在我们看来，BTA stat Test可以取代细胞学分析在膀胱癌诊断中的使用，但不能取代膀胱镜检查的使用。泌尿学57：685-689，2001年。(C)2001年，Elsevier Science Inc.
Objectives. To evaluate the usefulness of the Bard BTA stat Test in the diagnosis and follow-up of bladder cancer and to compare this test to cytologic analysis and cystoscopy, routine diagnostic methods.Methods. Three hundred seventy-nine patients being followed up because of bladder cancer or with symptoms suggestive of bladder cancer underwent cystoscopy, cytologic analysis, and the BTA stat Test using a recently voided urine sample. In suspected cases, transurethral resection and histopathologic analysis were performed.Results. Of the 379 patients, 235 proved to have bladder cancer and 144 did not. The sensitivity was 73.62% for the BTA stat, 61.70% for cytologic examination, and 99.57% for cystoscopy The specificity was 83.33% for the BTA stat, 92.36% for cytologic analysis, and 85.42% for cystoscopy. The BTA stat Test's sensitivity for grades 1, 2, and 3 tumor was 47.27%, 69.15%, and 95.35%, respectively. The sensitivity of cytologic analysis was 30.91%, 55.32%, and 88.37%. The BTA stat Test's sensitivity for stage was 45.65% in Stage Ta, 75.52% in T1, and 95.56% in Stage T2-4; the cytologic results were 28.26%, 65.03%, and 84.44%, respectively. The combination of both tests improved the sensitivity and decreased the specificity slightly.Conclusions. The high sensitivity of the BTA stat Test, together with the data obtained from the parameters used for the evaluation of the test, demonstrate the better results of the BTA stat Test compared with cytologic analysis, making it a thoroughly valid diagnostic tool in the diagnosis of bladder cancer. In our opinion, the BTA stat Test can replace the use of cytologic analysis in the diagnosis of bladder cancer, but not the use of cystoscopy. UROLOGY 57: 685-689, 2001. (C) 2001, Elsevier Science Inc.