Neuronal activity in dorsal anterior cingulate cortex during economic choices under variable action costs.
Neuronal activity in dorsal anterior cingulate cortex during economic choices under variable action costs.
复制标题
DOI：
10.7554/elife.71695
复制
发表时间：
2021-10-13
期刊：
影响因子：
7.7
通讯作者：
Padoa-Schioppa C
中科院分区：
文献类型：
--
作者：
Cai X;Padoa-Schioppa C
背前扣带皮层（ACCd）在决策中的作用经常被讨论，但仍然有些不清楚。一方面，许多研究表明，这一区域在努力或行动成本驱动的决策中。另一方面，对商品之间的经济选择（在固定行动成本下）的研究发现，ACCd中的神经元只编码决策后变量。为了加深我们对这一区域在决策中所起作用的理解，我们训练猴子在不同数量和不同行动成本的不同商品（果汁类型）之间做出选择。重要的是，任务设计将行动成本的计算与任何特定行动的计划分离开来。ACCd中的神经元在几个参考框架（选择果汁、选择成本、选择动作）中编码选择值和二元选择结果。因此，该区域提供了决策后变量的丰富表示。与OFC相比，ACCd中的神经元不代表任何参考框架中的预决策变量，如个人报价值。因此，正在进行的决策不太可能受到ACCd的指导。相反，该区域的神经元活动可能会通知随后的动作。
The role of the dorsal anterior cingulate cortex (ACCd) in decision making has often been discussed but remains somewhat unclear. On the one hand, numerous studies implicated this area in decisions driven by effort or action cost. On the other hand, work on economic choices between goods (under fixed action costs) found that neurons in ACCd encoded only post-decision variables. To advance our understanding of the role played by this area in decision making, we trained monkeys to choose between different goods (juice types) offered in variable amounts and with different action costs. Importantly, the task design dissociated computation of the action cost from planning of any particular action. Neurons in ACCd encoded the chosen value and the binary choice outcome in several reference frames (chosen juice, chosen cost, chosen action). Thus, this area provided a rich representation of post-decision variables. In contrast to the OFC, neurons in ACCd did not represent pre-decision variables such as individual offer values in any reference frame. Hence, ongoing decisions are unlikely guided by ACCd. Conversely, neuronal activity in this area might inform subsequent actions.