UTERINE EXPRESSION OF LEUKEMIA INHIBITORY FACTOR COINCIDES WITH THE ONSET OF BLASTOCYST IMPLANTATION
UTERINE EXPRESSION OF LEUKEMIA INHIBITORY FACTOR COINCIDES WITH THE ONSET OF BLASTOCYST IMPLANTATION
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DOI：
10.1073/pnas.88.24.11408
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发表时间：
1991-12-01
影响因子：
11.1
通讯作者：
STEWART, CL
中科院分区：
文献类型：
--
作者：
BHATT, H;BRUNET, LJ;STEWART, CL
我们分析了细胞因子白血病抑制因子（LIF）在胚胎发生和新生和成年小鼠组织中的表达。LIF表达最丰富的部位是子宫内膜腺，特别是在怀孕第4天。对假妊娠小鼠和延迟着床雌性小鼠的LIF表达分析表明，LIF受母体控制，其表达与囊胚形成一致，且总是在着床前。这些结果表明，体内LIF的一个主要功能可能是调节囊胚的生长和启动着床。
We have analyzed the expression of the cytokine leukemia inhibitory factor (LIF) during embryogenesis and in tissues of neonatal and adult mice. The site of the most abundant LIF expression is the uterine endometrial glands, specifically on day 4 of pregnancy. Analysis of LIF expression in pseudopregnant mice and in females undergoing delayed implantation showed that it is under maternal control and that its expression coincides with blastocyst formation and always precedes implantation. These results suggest that a principal function of LIF in vivo may be to regulate the growth and to initiate implantation of blastocysts.