Spermidine/spermine-N¹-acetyltransferase in kidney ischemia reperfusion injury.
Spermidine/spermine-N¹-acetyltransferase in kidney ischemia reperfusion injury.
复制标题
亚精胺/精胺-N-乙酰转移酶在肾缺血再灌注损伤中的作用。
DOI：
10.1007/978-1-61779-034-8_24
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Soleimani,Manoocher
中科院分区：
文献类型：
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作者：
Zahedi,Kamyar;Soleimani,Manoocher
缺血性再灌注损伤如急性肾功能衰竭、急性肝功能衰竭、中风和心肌梗死是发病率和死亡率的普遍原因。肾缺血再灌注损伤是急性肾功能衰竭和移植肾功能障碍的主要原因。尽管在解释导致缺血性再灌注损伤的因素方面取得了重大进展，但对这些损伤的治疗选择仍然很少。确定导致缺血再灌注损伤的分子，并将其作为治疗靶点，将有助于开发治疗此类损伤的新方法。肾缺血再灌注损伤后，亚精胺/精胺- n1 -乙酰转移酶表达增加。此外，亚精胺/精胺- n1 -乙酰转移酶基因失活可降低缺血再灌注损伤后肾损伤的严重程度。培养细胞中亚精胺/精胺- n1 -乙酰转移酶的表达增强导致DNA损伤、细胞周期阻滞和细胞基质相互作用的破坏。上述观察结果强烈提示，多胺反转化增强在肾缺血再灌注损伤中介导组织损伤中起重要作用。
Ischemic reperfusion injuries such as acute renal failure, acute liver failure, stroke, and myocardial infarction are prevalent causes of morbidity and mortality. Kidney ischemic reperfusion injury is the leading cause of acute renal failure and dysfunction of transplanted kidneys. Although significant progress has been made in deciphering the factors that contribute to ischemic reperfusion injury, treatment options for these injuries remain scant. Identifying the molecules that contribute to ischemic reperfusion injury and can be therapeutically targeted will lead to development of new approaches for the treatment of such injuries. The expression of spermidine/spermine-N1-acetyltransferase increases in the kidneys subjected to ischemic reperfusion injury. Furthermore, inactivation of the spermidine/spermine-N1-acetyltransferase gene reduces the severity of kidney damage after ischemic reperfusion injury. Enhanced expression of spermidine/spermine-N1-acetyltransferase in cultured cells leads to DNA damage, cell cycle arrest, and disruption of cell matrix interactions. The aforementioned observations strongly suggest that enhanced polyamine back conversion plays an important role in the mediation of tissue damage in renal Ischemic reperfusion injury.