The discovery of GSK221149A: A potent and selective oxytocin antagonist
The discovery of GSK221149A: A potent and selective oxytocin antagonist
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DOI：
10.1016/j.bmcl.2007.11.008
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发表时间：
2008-01-01
影响因子：
2.7
通讯作者：
Hickey, Deirdre M. B.
中科院分区：
文献类型：
--
作者：
Liddle, John;Allen, Michael J.;Hickey, Deirdre M. B.
一系列恶唑二酮哌嗪的优化导致发现了非常有效和选择性的催产素拮抗剂GSK221149A。GSK221149A已被证明可抑制麻醉大鼠中催产素诱导的子宫收缩。(C)2007爱思唯尔有限公司保留所有权利。
Optimisation of a series of oxazole diketopiperazines has led to the discovery of a very potent and selective oxytocin antagonist GSK221149A. GSK221149A has been shown to inhibit oxytocin-induced uterine contractions in the anaesthetised rat. (C) 2007 Elsevier Ltd. All rights reserved.