Checkerboard assessments of serum antibodies to oral micrabiota as surrogate markers of clinical periodontal status
Checkerboard assessments of serum antibodies to oral micrabiota as surrogate markers of clinical periodontal status
复制标题
DOI：
10.1034/j.1600-051x.2001.280116.x
复制
发表时间：
2001-01-01
影响因子：
6.7
通讯作者：
Dahlén, G
中科院分区：
文献类型：
--
作者：
Papapanou, PN;Neiderud, AM;Dahlén, G
工作背景：本研究探讨了口腔细菌血清IgG抗体的棋盘评估是否可以作为临床牙周状况的替代标记物在流行病学研究中。方法：分析涉及的数据从205名受试者，132名牙周炎患者和73名牙周完整的对照，从他们的全口临床牙周数据和血清IgG滴度对19种牙周细菌。结果：一个包含6个菌种滴度的logistic回归模型（牙龈卟啉单胞菌、伴放线放线杆菌、结节真杆菌、腐蚀艾肯氏菌、赭红色二氧化碳噬纤维菌和内氏放线菌基因种2）对74.5%的受检者进行了正确分类，灵敏度为84%，特异性为57.5%，阳性预测值为78%，阴性预测值为66.7%。当临床牙周状况的数据不容易获得时，生物标记板血清学可用于提供替代标记，因此，可以作为一个有价值的补充，在医疗设备的流行病学工具，适合牙周病的研究。
Background: This study addresses whether checkerboard assessments of serum IgG antibodies to oral bacteria may serve as surrogate markers of clinical periodontal status in epidemiologic studies.Method: The analysis involved data from 205 subjects, 132 periodontitis patients and 73 periodontally-intact controls, from whom full-mouth clinical periodontal data and serum IgG titers against 19 periodontal bacterial species were available.Results: A logistic regression model involving titers against 6 species (Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Eubacterium nodatum, Eikenella corrodens, Capnocytophaga ochracea and Actinomyces naeslundii genospecies 2) classified correctly 74.5% of the subjects examined, with 84% sensitivity, 57.5% specificity, 78% positive predictive value and 66.7% negative predictive value.Conclusions: Checkerboard serology may be useful in providing surrogate markers for clinical periodontal status when such data are not readily available and, thus may serve as a valuable complement in the armamentarium of epidemiologic tools suited for the study of periodontal diseases.