A 6-YEAR FOLLOW-UP OF BEHAVIOR AND ACTIVITY DISORDERS IN THE TAIWAN YU-CHENG CHILDREN
A 6-YEAR FOLLOW-UP OF BEHAVIOR AND ACTIVITY DISORDERS IN THE TAIWAN YU-CHENG CHILDREN
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DOI：
10.2105/ajph.84.3.415
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发表时间：
1994-03-01
影响因子：
12.7
通讯作者：
HSU, CC
中科院分区：
文献类型：
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作者：
CHEN, YCJ;YU, MLM;HSU, CC
目标.本研究探讨台湾育城儿童在子宫内暴露于热降解多氯联苯（PCBs）的行为和活动水平与爆发和出生年份之间的间隔以及儿童年龄的关系。此外，还描述了评分与化学、物理和认知结果的关系。方法。采用Rutter儿童行为量表A和修订的Werry-Weiss-Peters活动量表，对禹城市118名儿童和对照组儿童进行了半年一次的追踪调查。每年，渝城儿童在Rutter量表上的得分比对照组儿童差7%至43%（平均值= 23%）。在任何一个固定的年龄段，禹城儿童的得分都要低11%到63%（平均值= 28%）。对晚出生的孩子的影响与早出生的孩子没有区别;随着孩子年龄的增长，也没有任何改善。活动评分也有类似但较弱的情况。这些行为研究结果与身体或认知研究结果或血清PCB水平无关。在子宫内暴露于热降解的多氯联苯似乎会导致轻度的行为紊乱和活动水平增加;随着时间的推移，这种影响会持续下去，并且在母亲暴露后6年内出生的儿童中也是如此。
Objectives. The relationship of behavior and activity levels to the interval between outbreak and year of birth and to age of the children is explored in Taiwanese children exposed in utero to heat-degraded polychlorinated biphenyls (PCBs)-the Yu-cheng children. Additionally, the relationship of the scores to chemical, physical, and cognitive findings is described.Methods. With Rutter's Child Behavior Scale A and a modified Werry-Weiss-Peters Activity Scale, 118 Yu-cheng children and matched controls were followed biannually from 1985 to 1991.Results. At each year, the Yu-cheng children scored 7% to 43% worse (mean = 23%) than control children on the Rutter scale. At any fixed age, the Yu-cheng children scored 11% to 63% (mean = 28%) worse. The effect for children born later did not differ from that for those born earlier; neither was there any improvement as the children aged. A similar but weaker picture was seen for the activity score. These behavioral findings were not related to physical or cognitive findings or to serum PCB levels.Conclusions. Inutero exposure to heat-degraded PCBs appears to cause mildly disordered behavior and increased activity level; the effect persists over time and is similar in children born up to 6 years after the mothers were exposed.