The diversity expression of p62 in digestive system cancers
The diversity expression of p62 in digestive system cancers
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DOI：
10.1016/j.clim.2005.04.004
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发表时间：
2005-08-01
影响因子：
8.6
通讯作者：
Peng, XX
中科院分区：
文献类型：
--
作者：
Su, YX;Qian, HL;Peng, XX
p62自身抗原的表达和p62自身抗体的频率分别在肝细胞癌（HCC）和许多类型的恶性肿瘤中有报道，但关于p62在其他癌症组织中的表达以及p62自身抗体与肿瘤行为的关系的信息尚不清楚。本研究分别采用免疫组化染色和ELISA法检测胃癌、食管癌、大肠癌和HCC四种临床类型消化系统肿瘤组织中p62的表达和血清中p62自身抗体的出现情况。有趣的是，p62的免疫组化染色在所有消化道组织（胃、食道、大肠）中均可见，包括癌组织、癌旁组织和非恶性患者，而在HCC患者的癌旁组织和癌旁组织中p62的频率分别为62.5%和0%。重要的是，我们发现p62的表达和p62自身抗体的频率分别与细胞分化和肿瘤转移有关。这些结果提示p62在组织中的表达和血清中p62自身抗体的出现可能与细胞恶性表现有关。此外，p62自身抗体是癌症预后和临床治疗评价的重要标志。(c) 2005爱思唯尔公司版权所有。
The expression of p62 autoantigen and the frequency of p62 autoantibody have been reported in hepatocellular carcinoma (HCC) and many types of malignant tumors, respectively, but information regarding to the expression of p62 in other cancer tissues and the association of autoantibody to p62 with tumor behaviors is not available. In the current study, the expression of p62 in tissues and the appearance of p62 autoantibody in sera were detected by immunohistochemical staining and ELISA in four clinical types of digestive system cancers including gastric cancer, esophageal cancer, large intestine cancer and HCC, respectively. Interestingly, the immunohistochemistry staining of p62 has been shown in all of digestive canal tissues (stomach, esophagus, large intestine) including tissues with cancers, beside cancers and from nonmalignant patients, whereas the frequencies were 62.5% and 0% in tissues with cancer and beside cancer in patients with HCC, respectively. Importantly, we found that the p62 expression and the frequency of autoantibody to p62 were associated to cell differentiation and tumor metastasis, respectively. These results suggest that the expression of p62 in tissues and the appearance of autoantibody to p62 in sera might be related to cell malignant manifestations. Moreover, p62 autoantibody is a significant marker for the prognosis of cancers and the evaluation of clinical treatments. (c) 2005 Elsevier Inc. All rights reserved.