Influence of light at night on murine anxiety- and depressive-like responses
Influence of light at night on murine anxiety- and depressive-like responses
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DOI：
10.1016/j.bbr.2009.07.001
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发表时间：
2009-12-28
影响因子：
2.7
通讯作者：
Nelson, Randy J.
中科院分区：
文献类型：
--
作者：
Fonken, Laura K.;Finy, M. Sima;Nelson, Randy J.
人们越来越多地在夜间暴露在光线下。暴露于恒定的光（LL）破坏昼夜节律的运动活动，体温，激素和睡眠-觉醒周期的动物其他行为反应LL已被报道，但不一致：本实验试图确定是否LL产生的情感反应的变化，以及是否行为变化是由糖皮质激素浓度的改变介导的。相对于同种保持在一个光/暗周期（LD，16.8光/暗），暴露于LL三周的雄性瑞士韦伯斯特小鼠增加抑郁样行为反应，通过强迫游泳试验和蔗糖anhemorrhage评价。此外，提供一个光逃逸管逆转LL在强迫游泳试验中的影响。LL小鼠表现出减少的焦虑，通过开放领域和高架十字迷宫评估。糖皮质激素浓度降低的LL组表明，LL的情感行为反应是不是皮质酮升高的结果。此外，与LL小鼠相比，在具有透明管的LD中饲养的小鼠显示出增加的配对睾丸质量。总而言之，这些数据提供了证据，表明暴露于不自然的照明可以引起影响的显着变化，增加抑郁样反应和减少焦虑样反应。(C)2009 Elsevier B.V版权所有
Individuals are increasingly exposed to light at night. Exposure to constant light (LL) disrupts circadian rhythms of locomotor activity, body temperature, hormones, and the sleep-wake cycle in animals Other behavioural responses to LL have been reported, but are inconsistent: The present experiment sought to determine whether LL produces changes in affective responses and whether behavioural changes are mediated by alterations in glucocorticoid concentrations. Relative to conspecifics maintained in a light/dark cycle (LD, 16.8 light/dark), male Swiss-Webster mice exposed to LL for three weeks increased depressive-like behavioural responses as evaluated by the forced swim test and sucrose anhedoma Furthermore, providing a light escape tube reversed the effects of LL in the forced swim test. LL mice displayed reduced anxiety as evaluated by the open field and elevated-plus maze. Glucocorticoid concentrations were reduced in the LL group suggesting that the affective behavioural responses to LL are not the result of elevated corticosterone. Additionally, mice housed in LD with a clear tube displayed increased paired testes mass as compared to LL mice. Taken together, these data provide evidence that exposure to unnatural lighting can induce significant changes in affect, increasing depressive-like and decreasing anxiety-like responses. (C) 2009 Elsevier B.V All rights reserved