The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development
The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development
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微球蛋白 1 (MCRS1) 在基因表达、细胞增殖和有机体发育中的分子特征和功能作用
DOI：
10.1080/15384101.2022.2145816
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发表时间：
2022-11-18
期刊：
影响因子：
4.3
通讯作者：
Kang，Jungseog
中科院分区：
文献类型：
--
作者：
Huang，Ching-Jung;Lyu，Xiaoai;Kang，Jungseog
细胞周期进程的精确时空调控对细胞增殖和器官发育至关重要。本文综述了微球蛋白58kD（MCRS 1）作为高等真核生物细胞周期调控因子的作用。我们讨论了MCRS1的亚型和功能域，以及它们在细胞周期的特定阶段的亚细胞定位。这些分子特征揭示了MCRS1在基因表达、基因组稳定性、细胞增殖和器官发育中的动态调节作用。此外，我们还讨论了其在不同类型癌症中看似相反的肿瘤抑制或肿瘤促进作用的分子细节。
ABSTRACT Accurate spatial and temporal regulation of cell cycle progression is essential for cell proliferation and organismic development. This review demonstrates the role of microspherule protein 58kD, commonly known as MCRS1, as a key cell cycle regulator of higher eukaryotic organisms. We discuss the isoforms and functional domains of MCRS1 as well as their subcellular localization at specific stages of the cell cycle. These molecular characteristics reveal MCRS1’s dynamic regulatory role in gene expression, genome stability, cell proliferation, and organismic development. Furthermore, we discuss the molecular details of its seemingly opposite, tumor-suppressive or tumor-promoting, role in different types of cancer.